Bazer FW, Wu G, Spencer TE, Johnson GA, Burghardt RC, Bayless K. Novel pathways for implantation and establishment and maintenance of pregnancy in mammals. Mol Hum Reprod. 2010;16:135–52.
Bazer FW, Kim J, Song G, Ka H, Tekwe CD, Wu G. Select nutrients, progesterone, and interferon tau affect conceptus metabolism and development. Ann N Y Acad Sci. 2012;1271:88–96.
Gray C, Burghardt RC, Johnson GA, Bazer FW, Spencer TE. Evidence that absence of endometrial gland secretions in uterine gland knockout ewes compromises conceptus survival and elongation. Reproduction. 2002;124:289–300.
Gray CA, Abbey CA, Beremand PD, Choi Y, Farmer JL, Adelson DL, et al. Identification of endometrial genes regulated by early pregnancy, progesterone, and interferon tau in the ovine uterus. Biol Reprod. 2006;74:383–94.
Kwon H, Wu G, Bazer FW, Spencer TE. Developmental changes in polyamine levels and synthesis in the ovine conceptus. Biol Reprod. 2003;69:1626–34.
Moinard C, Cynober L, de Bandt JP. Polyamines: metabolism and implications in human diseases. Clin Nutr. 2005;24:184–97.
Igarashi K, Kashiwagi K. Modulation of protein synthesis by polyamines. IUBMB Life. 2015;67:160–9.
Agostinelli E. Polyamines and transglutaminases: biological, clinical, and biotechnological perspectives. Amino Acids. 2014;46:475–85.
Wu G, Bazer FW, Satterfield MC, Li X, Wang X, Johnson GA, et al. Impacts of arginine nutrition on embryonic and fetal development in mammals. Amino Acids. 2013;45:241–56.
Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. J Biochem. 1998;336:1–17.
Wu G, Meininger CJ. Arginine nutrition and cardiovascular function. J Nutr. 2000;130:2626–9.
Zeng X, Wang F, Fan X, Yang W, Zhou B, Li P, et al. Dietary arginine supplementation during early pregnancy enhances embryonic survival in rats. J Nutr. 2008;138:1421–5.
Wu G, Bazer FW, Davis TA, Kim SW, Li P, Marc Rhoads J, et al. Arginine metabolism and nutrition in growth, health and disease. Amino Acids. 2009;37:153–68.
Bazer FW, Johnson GA, Wu G. Amino acids and conceptus development during the peri-implantation period of pregnancy. Adv Exp Med Biol. 2015;843:23–52.
Wang X, Frank JW, Little DR, Dunlap KA, Satterfield MC, Burghardt RC, et al. Functional role of arginine during the peri-implantation period of pregnancy. I. Consequences of loss of function of arginine transporter SLC7A1 mRNA in ovine conceptus trophectoderm. FASEB. 2014;28:2852–63.
Wang X, Johnson GA, Burghardt RC, Wu G, Bazer FW. Uterine histotroph and conceptus development. II. Arginine and secreted phosphoprotein 1 cooperatively stimulate migration and adhesion of ovine trophectoderm cells via focal adhesion-mtorc2 mediated cytoskeleton reorganization. Biol Reprod. 2016;95:71.
Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R, Reis DJ. Agmatine: an endogenous clonidine-displacing substance in the brain. Science. 1994;263:966–9.
Li G, Regunathan S, Reis D. Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat brain. Ann N Y Acad Sci. 1995;763:325–9.
Reis DJ, Regunathan S. Agmatine: an endogenous ligand at imidazoline receptors is a novel neurotransmitter. Ann N Y Acad Sci. 1999;881:65–80.
Piletz JE, Aricioglu F, Cheng JT, Fairbanks CA, Gilad VH, Haenisch B, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today. 2013;18:880–93.
Lenis YY, Wang X, Tang W, Wu G, Bazer FW. Effects of agmatine on secretion of interferon tau and catecholamines and expression of genes related to production of polyamines by ovine trophectoderm cells. Amino Acids. 2016;48:2389–99.
Wang X, Frank JW, Xu J, Dunlap KA, Satterfield MC, Burghardt RC, et al. Functional role of arginine during the peri-implantation period of pregnancy. II. Consequences of loss of function of nitric oxide synthase NOS3 mRNA in ovine conceptus trophectoderm. Biol Reprod. 2014b;91:59.
Wang X, Wei Y, Dunlap KA, Lin G, Satterfield MC, Burghardt RC, et al. Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses. Biol Reprod. 2014;90:84.
Ruiz GI, Minten M, Wang X, Dunlap KA, Bazer FW. Involvement of TLR7 and TLR8 in conceptus development and establishment of pregnancy in sheep. Reproduction. 2015;149:305–16.
Antoniazzi A, Webb B, Romero J, Ashley R, Smirnova N, Henkes L, et al. Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 alpha-induced luteolysis in ewes. Biol Reprod. 2013;88:144.
Kim JY, Spencer TE, Burghardt RC, Wu G, Johnson GA, Bazer FW. Arginine stimulates proliferation of ovine trophectoderm cells through FRAP1-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines. Biol Reprod. 2009;81:488–96.
Kim JY, Burghardt RC, Wu G, Johnson GA, Spencer TE, Bazer FW. Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration. Biol Reprod. 2011;84:62–9.
Arques O, Chicote I, Tenbaum S, Puig I, Palmer HG. Standardized relative quantification of immunofluorescence tissue staining. Protocol Exchange published online, doi.;10.
Dai Z, Wu Z, Wang, Jia S, Bazer FW, Wu G. Analysis of polyamines in biological samples by HPLC involving pre-column derivatization with O-phthalaldehyde and N-acetyl-L-cysteine. Amino Acids. 2014;46:1557–64.
Kohli R, Meininger CJ, Haynes TE, Yan W, Self JT, Wu G. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J Nutr. 2004;134:600–8.
Jobgen W, Meininger CJ, Jobgen SC, Li P, Lee MJ, Smith SB, et al. Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. J Nutr. 2009;139:230–7.
Bazer FW, Spencer TE, Ott T. Interferon tau: a novel pregnancy recognition signal. Am J Reprod Immunol. 1997;37:412–20.
Johnson GA, Spencer TE, Burghardt RC, Joyce MM, Bazer FW. Interferon-tau and progesterone regulate ubiquitin cross-reactive protein expression in the ovine uterus. Biol Reprod. 2000;62:622–7.
Spencer TE, Becker WC, George P, Mirando MA, Ogle TF, Bazer FW. Ovine interferon-tau regulates expression of endometrial receptors for estrogen and oxytocin but not progesterone. Biol Reprod. 1995;5:732–45.
Spencer TE, Gray A, Johnson GA, Taylor KM, Gertler A, Gootwine E, et al. Effects of recombinant ovine interferon tau, placental lactogen, and growth hormone on the ovine uterus. Biol Reprod. 1999;61:1409–18.
Spencer TE, Bazer FW. Uterine and placental factors regulating conceptus growth in domestic animals. J Anim Sci. 2004;82:4–13.
Bazer FW, Spencer TE, Johnson GA, Burghardt RC. Uterine receptivity to implantation of blastocysts in mammals. Front Biosci (Schol Ed). 2010;3:745–67.
Bazer FW, Wu G, Johnson GA, Kim J, Song G. Uterine histotroph and conceptus development: select nutrients and secreted phosphoprotein 1 affect mechanistic target of rapamycin cell signaling in ewes. Biol Reprod. 2011;85:1094–107.
Spencer TE, Johnson GA, Bazer FW, Burghardt RC. Implantation mechanisms: insights from the sheep. Reproduction. 2004;128:657–68.
Kwon H, Ford SP, Bazer FW, Spencer TE, Nathanielsz PW, Nijland MJ, et al. Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids. Biol Reprod. 2004;71:901–8.
Sawicki J, Impellizeri A, O'Brien T. Effects of exogenous putrescine on murine preimplantation development in vitro. Dev Biol. 1991;148:620–4.
Tao Y, Liu D, Mo G, Wang H, Liu XJ. Peri-ovulatory putrescine supplementation reduces embryo resorption in older mice. Hum Reprod. 2015;30:1867–75.
Gao H, Wu G, Spencer TE, Johnson GA, Bazer FW. Select nutrients in the ovine uterine lumen. II. Glucose transporters in the uterus and peri-implantation conceptuses. Biol Reprod. 2009;80:94–104.
Zhao YC, Chi YJ, Yu YS, Liu JL, Su RW, Ma XH, et al. Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period. Endocrinology. 2008;149:2325–32.
Lefèvre PL, Palin MF, Murphy B. Polyamines on the reproductive landscape. Endocr Rev. 2011;32:694–712.
Wu G, Davis PK, Flynn NE, Knabe DA, Davidson JT. Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs. J Nutr. 1997;27:2342–9.
Gao H, Wu G, Spencer T, Johnson GA, Li X, Bazer F. Select nutrients in the ovine uterine lumen. I. Amino acids, glucose, and ions in uterine lumenal flushings of cyclic and pregnant ewes. Biol Reprod. 2009;80:86–93.
Wu G, Bazer FW, Cudd TA, Meininger CJ, Spencer TE. Maternal nutrition and fetal development. J Nutr. 2004;134:2169–72.
Bazer FW, Wu G, Johnson GA, Wang X. Environmental factors affecting pregnancy: endocrine disrupters, nutrients and metabolic pathways. Mol Cell Endocrinol. 2014;398:53–68.
Kong X, Wang X, Yin Y, Li X, Gao H, Bazer FW, Wu G. Putrescine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells. Biol Reprod. 2014;91:106.
Wang X, Burghardt RC, Romero JJ, Hansen TR, Wu G, Bazer FW. Functional roles of arginine during the peri-implantation period of pregnancy. III. Arginine stimulates proliferation and interferon tau production by ovine trophectoderm cells via nitric oxide and polyamine-TSC2-MTOR signaling pathways. Biol Reprod. 2015;92:75.
Wu G, Bazer FW, Hu J, Johnson GA, Spencer TE. Polyamine synthesis from proline in the developing porcine placenta. Biol Reprod. 2005;72:842–50.
Wu G, Bazer FW, Datta S, Johnson GA, Li P, Satterfield MC, et al. Proline metabolism in the conceptus: implications for fetal growth and development. Amino Acids. 2008;35:691–702.