Fig. 6

Knockdown of translation of both ODC1 and ADC mRNAs resulted in two phenotypes of conceptuses: 33 % had the (MAO-ODC1:MAO-ADC (a) normal phenotype, while 66 % of MAO-ODC1:MAO-ADC (b) conceptuses had an abnormal phenotype with respect to morphology, production of interferon tau (IFNT), and and amino acids and polyamines in uterine flushings. MAO-ODC1:ADC (a) conceptuses had an elongated morphology with normal production of IFNT, greater amount of agmatine (Agm), putrescine, and spermidine in conceptus tissue, and greater amount of aspartate (Asp), glutamate (Glu), citrulline (Cit), arginine (Arg), tyrosine (Tyr), phenylalanine (Phe), isoleucine (Ile), leucine (Leu) and lysine (Lys) in uterine flushings than was the case for MAO-ODC1:MAO-ADC (b) conceptuses. The pathways involving ODC1 and ADC for synthesis of nitric oxide and polyamines is noted and their locations are noted by the green X and the red X, respectively