Clays as dietary supplements for swine: A review
© Subramaniam and Kim. 2015
Received: 11 June 2015
Accepted: 30 July 2015
Published: 22 August 2015
Clays are crystalline, hydrated aluminosilicate molecules composed of alkali and alkaline earth cations along with small amounts of various other elements. The best-known are montmorillonite, smectite, illite, kaolinite, biotite and clinoptilolite. The molecules in these clays are arranged in three-dimensional structures creating internal voids and channels capable of trapping a wide variety of molecules. As a result of this structure, clay minerals are regarded as a simple and effective tool for the prevention of the negative effects of many toxic compounds. Dietary supplementation with clays has been shown to improve weight gain and feed conversion in pigs. Where improvements in performance have been noted, one of the most likely explanations for the improvement is the fact clays increase nutrient digestibility. Clays reduce the speed of passage of feed along the digestive tract which allows more time for digestion. Feeding clays also causes morphological changes in the intestinal mucosa such as an increase in villus height and an increase in the villus height to crypt depth ratio. These changes increase the surface area of the gastrointestinal tract thus increasing nutrient digestibility. Several studies have indicated that feeding clay reduces the incidence, severity and duration of diarrhea in pigs. The mechanism for the reduction in diarrhea is likely due to increases in the numbers of Bifidobacteria and Lactobacillus and decreases in Clostridia and E. coli in the small intestine of pigs fed clays. In addition, the numbers of pigs born alive and weaned, birth weight and weaning weight have been shown to be higher for sows fed clays. Several studies have indicated that clays can help mitigate the effects of mycotoxins. The aim of the present review is to focus on the various clays which have been given attention in recent research and to discuss their potential to improve pig performance.
Antibiotics are compounds used as growth promoters in animal feeds to decrease the animal’s susceptibility to infectious agents . The use of antibiotics has been forbidden in the European Union since 2006 and many other countries are considering similar bans. As a result, intensive research has been focused on the development of alternative feeding strategies that can maintain pig performance and health [2–4]. One product class that has been suggested as an alternative feed additive for use in the pig industry is the inert clays [5–9].
Clays are crystalline, hydrated aluminosilicate molecules composed of alkali and alkaline earth cations along with small amounts of various other elements . The molecules in these clays are arranged in three-dimensional structures creating internal voids and channels capable of trapping a wide variety of molecules . As a result of this structure, clay minerals are regarded as a simple and effective tool for the prevention of the negative effects of toxic compounds.
Clays added to the diet can bind and immobilize toxic materials in the gastrointestinal tract of animals and reduce their toxicity. Several studies have confirmed the decontamination properties of clays against mycotoxins [11–17], heavy metals [18–24], and other toxins . The adsorption capacity for any specific clay is determined by the fine structure of the clay particles, their surface properties and exchangeable ions . Clays have also been shown to have a significant influence on growth, nutrient digestibility and the reproductive performance of swine. The aim of the present review is to focus on the various clays which have been given attention in recent research and to discuss their potential to improve pig performance.
Structure of clays
Clays are naturally occurring minerals with a particle size less than 2 um in diameter . They are composed mainly of phyllosilicates . Phyllosilicates occur in layers and are classified according to the type of layers they possess, their interlayer content, the electronic charge of the layers and their chemical formula . The structure of a phyllosilicate is based on a tetrahedral sheet of cations (commonly Si4+, Al3+ and Fe3+) and octahedral sheets of cations (commonly Al3+, Fe3+, Mg2+ and Fe2+). These layers have been classified into 1:1, 2:1 or framework structures .
Clays with a 1:1 layer structure typically have a tetrahedral Si sheet covalently bound to an octahedral Al sheet. Examples of this type of clay are kaolinite, dickite and nacrite, which belong to the kaolin group . Clays classified as 2:1 layer structures have an octahedral sheet (Al, Mg or Al and Mg) between 2 tetrahedral Si sheets. Examples of this type of clay are montmorillonite, saponite, hectorite and beidellite which belong to the smectite group as well as illite, chlorite and vermiculite . Zeolite is an example of a clay with a framework structure. These are a three dimensional tetrahedral structure of SiO4 4− , and AlO4 5− linked through shared oxygen atoms .
The structure and composition of the clay determines their physical and chemical properties. For example, smectites and illite have spaces between their layers that can expand to accommodate water and cations, allowing exceptional water absorption. As a result, they are able to absorb up to half their mass in water . Monmorillonite is formed by a 2:1 condensation of layers of octahedrally coordinated aluminum sandwiched between two layers of tetrahedrally coordinated silica . Montmorilonite has a electronic charge imbalance due to the replacement of Al3+ for Si4+ in the tetrahedral layer and Mg2+ or Zn2+ for Al3+ in the octahedral layer resulting in a negative charge at the clay surface. Monmorillonite can adsorb organic materials either on its surface or within its inter-laminar spaces through an exchange of cations present in these spaces, Due to these physical-chemical properties, montmorillonite has been extensively used in animal diets to promote production, reduce the detrimental effects induced by mycotoxin-contaminated feeds and protect against enteric diseases in swine .
Smetities have medium to high cation exchange capacity, high surface area, high adsorption capacity and high viscosity. Kaolin minerals (kaolinite, dickite, nacrite and halloysite) have minimal net charge but have properties such as very low cation exchange capacity, low surface area, and low adsorption capacity. Zeolites have three dimensional channel surfaces that can trap molecules according to the dimensions of the channel. Exchange of cations and water takes place within the three-dimensional channel structures present in the zeolite. They have a negative charge, high exchange capacity for certain cations (i.e. NH4 +) with their selectivity a function of their pore size and capacity to adsorb contaminants.
Use of clays to improve pig growth performance
The strategy of using clays to improve pig performance has been given considerable attention in research. Many studies have documented a significant improvement in weight gain and feed conversion in pigs fed diets supplemented with clays [6, 7, 26–31]. Improvements have been noted for both weanling pigs and growing-finishing pigs.
Effect of clay supplementation on the performance of weanling pigs
Clay (3 g/kg)1
Clay (6 g/kg)1
Day 0 to 7
Weight gain, g/day
Feed intake, g/day
Day 7 to 21
Weight gain, g/day
Feed intake, g/day
Day 21 to 35
Weight gain, g/day
Feed intake, g/day
Day 0 to 35
Weight gain, g/day
Feed intake, g/day
Effect of clinoptilolite on the performance of growing and finishing pigs
C x A
Day 25 to 70
Weight gain, kg/d
Feed intake, kg/d
Day 71 to 112
Weight gain, kg/d
Feed intake, kg/d
Weight gain, kg/d
Feed intake, kg/d
Day 25 to 161
Weight gain, kg/d
Feed intake, kg/d
Prvulovic et al.  reported a 7 % increase in weight gain and a 1.4 % improvement in FCR in growing pigs fed diets supplemented with 0.5 % clinoptilolite during the growing period while no improvement was noted during the finishing period. Yu et al.  reported that weight gain, feed intake and feed conversion ratio were improved by 8.9, 3.9 and 4.8 % as a result of feeding 0.5 % montmorillonite to growing pigs. Li and Kim  reported that growing pigs fed a diet supplemented with 0.5 % sericite had 6.6 % higher weight gain and a 5.1 % better feed conversion ratio compared with pigs fed an unsupplemented diet.
Alexopoulos et al.  compared the performance of pigs fed 2 % clinopilolite with the performance of pigs fed an unsupplemented control from 25 days of age until market weight at 161 days of age. They reported a 5.3 % improvement in weight gain for pigs fed clinopilolite. Again, the response was greater in younger pigs than older pigs. Pond et al.  reported that weight gain was increased by 14.3 % and feed conversion by 2.9 % as a result of feeding 2 % clinoptilolite to growing pigs.
Unfortunately, the effects of clay supplementation on pig performance have been inconsistent and there are many studies which have noted no improvements in pig performance as a result of feeding clays. Song et al.  reported no improvement in weight gain or feed conversion as a result of feeding 0.3 or 0.6 % smectite to weaned pigs. In a subsequent experiment, they compared smectite, kaolinite and zeolite fed individually and in all possible combinations to total 0.3 % of the diet and observed no improvements in pig performance. Xia et al.  reported no effect on pig performance from including 0.15 % montmorillonite in the diet of weanling pigs.
Chen et al. [8, 9] observed no improvement in growing-finishing pig performance for pigs fed 0.5 % Biotite (61.9 % SiO2, 23.19 % Al2O3, 3.97 % Fe2O3 and 3.35 % Na2O). Similarly, Thacker  fed 0, 0.25, 0.5 or 0.75 % Biotite during the growing period and 0, 0.5, 1.0 or 1.5 % during the finishing period and observed no improvement in pig performance. Yan et al. , fed the same composite clay as Yan et al.  and found no improvement in growing-finishing pig performance. In addition, Lin et al. , Yu et al. , Poulsen and Oksbjerg , Shurson et al. , Parisini et al. , Abranches et al.  and Han and Thacker  reported no improvements in pig performance as a result of dietary inclusion of clays.
As noted previously, the effect of clays on pig performance is inconsistent. In general, younger pigs respond more to dietary clay supplementation than older pigs [6, 28–30]. In addition, the level of supplementation affects the response. Supplementation of diets with 1 to 3 % clay is recommended [4, 6].
Use of clays to improve nutrient digestibility
Effects of including sericite in diets fed to growing pigs on the apparent total tract digestibility of nutrients
Level of sericite, %
Effects of clay supplementation on nutrient digestibility in growing-finishing pigs1
Level of clay (g/kg)
P - value
Chen et al.  reported that nitrogen and calcium digestibilities were increased by the addition of 0.5 % Biotite V to the diet while dry matter and phosphorus digestibilities were unaffected. In a subsequent experiment, Chen et al.  reported significant improvements in the digestibility of dry matter, nitrogen, calcium and phosphorus as a result of supplementation with either 1 or 2 % Biotite V.
In contrast, Thacker  and Han and Thacker  reported no improvement in nutrient digestibility as a result of including clays in the diet of growing-finishing pigs. Shurson et al.  reported negative effects on nutrient digestibility when diets containing 0, 2.5, 5.0 or 7.5 % clinopilolite were fed to starter pigs. Poulsen and Oksbjerg  also reported negative effects on dry matter and nitrogen digestibility as a result of feeding 3 % clinoptilolite to young growing pigs while Fokas et al.  indicated that clay (organozeolites) had no influence on nutrient utilization in growing pigs fed a zearalenol contaminated feed.
Effect of montmorillonite on the intestinal morphology in the jejunum
Villus height (um)
Crypt depth (um)
Villus height: crypt depth
Use of clays to reduce the incidence of diarrhea in swine
Effect of smectite on the diarrhea scores of pigs experimentally infected with a pathogenic E. coli
Level of smectite, %
There are several potential mechanisms through which clays may reduce the incidence of diarrhea in swine. Clays such as smectites and illite have spaces between their layers that can expand to accommodate water and cations, allowing exceptional water absorption. As a result, they are able to absorb up to half their mass in water . This would result in the presentation of a firmer feces and thus influence the presentation of diarrhea directly.
Effect of montmorillonite on the intestinal flora of weanling pigs (log10 CFU/g)
Additional mechanisms through which clays may reduce the incidence of diarrhea were reviewed by Song et al. . They suggested that clays may attract bacterial cells with enough physical force to tear the cell membrane resulting in lysis of the bacterial cells. Clays can also adsorb or detoxify bacterial toxins and thus protect pigs from increases in intestinal permeability and damage by toxins. In addition, clays may adhere to the gastrointestinal mucous membranes and reinforce the physical mucous barrier resulting in some protection against enteric diseases caused by bacteria.
Another mechanism through which clays can reduce the incidence of diarrhea is through increasing the numbers of goblet cells. Goblet cells produce mucins in the small intestine and these proteins comprise the bulk of the mucus layer which acts as the first line of defense against eneteric infections. Abranches et al.  observed a tendency for an increase in goblet cell size and number in the ileum of pigs fed smectite. The modest increase in goblet cell size and number when clays were fed may at least partially explain the reduction in diarrhea observed in pigs .
Concerning newborn animals, the administration of zeolites appears to reduce the incidence of diarrhea through the enhancement of passive immunity, as they increase the net absorption of colostrum immunoglobulins in pigs .
Other mechanisms to explain the growth promoting effects of clays
It has been suggested that growth and feed efficiency were improved due to the reduced microbial production of ammonium in the intestines when clays are fed . This lowers the nutritional demands for cell renewal and thereby increases the amount of nutrients available for growth .
Another potential explanation for the improved performance of pigs fed clays is the result of increased growth hormone levels. Yu et al.  reported that serum growth hormone peak, base-line levels and mean levels were increased by 117.1, 42.8 and 51.7 % in pigs fed 0.5 % montmorillonite.
Effect of clays on carcass traits
Little research has been conducted to determine the effects of dietary inclusion of clays on swine carcass traits. Thacker  reported that feeding clays did not affect dressing percentage, lean yield, loin fat, loin lean or carcass value index of pigs fed graded levels of Biotite. Similarly, Han and Thacker  reported no effects from feeding Hwangto clay on the percentages of tenderloin, bacon, fat and bone, skirt, fresh ham or ribs. However, pigs fed Hwango had a higher percentage of loin. Yan et al.  reported no effects on meat quality except that meat firmness was increased by 20.2 % for pigs fed 6 g/kg composite clay (Anion).
Reproduce performance of pigs fed clays
Effect of zeolites on sow fertility and diseases
Return to estrus
The effects of clinoptilolite on the reproductive performance of sows
Piglets born alive
Preweaning mortality, %
Birth weight, kg
Weaning weight, kg
Use of clay to reduce the effects of mycotoxins
One of the most important roles of clays for pigs is their ability to mitigate the effects of mycotoxins. Mycotoxins are toxic secondary metabolites of fungi commonly found on grains, which can cause severe negative impacts on swine health and performance. Clays may have the ability to diminish the impact of mycotoxins through their binding properties. Lindeman et al.  reported that inclusion of 0.5 % hydrated sodium calcium aluminosilicate or sodium bentonite in a diet with 840 ppm aflatoxin prevented most of the reductions in weight gain and feed intake observed in weanling pigs. Schell et al. [14, 15] reported similar findings.
Wang et al. , reported that the addition of montmorillonite clay to the diet can ameliorate the negative effects of dietary zearalanone and accelerate recovery of zearalanone toxicity in weaning pigs during and after zearalanone challenge (Table 10). In their experiment, nursery pigs were fed diets contaminated with 0, 0.2, 0.4 or 0.8 ppm zearalenone which depressed weight gain and negatively impacted feed efficiency. The addition of montmorillonite to the diet significantly improved the feed efficiency of pigs fed zeralanone. In addition, the total tract digestibility of nitrogen was improved by supplementation with montmorillonite while dry matter and energy digestibility were unaffected. Montmorillonite clay also improved the performance of growing gilts fed zearalenone contaminated diets. Wang et al.  reported significant improvements in weight gain and feed efficiency as a result of including 2 g/kg montmorillonite in diets contaminated with 0, 0.2, 0.4 or 0.8 ppm zearalenone (Table 11).
The effect of montmorillonite clay on the performance and total tract digestibility of nutrients in diets fed to nursery pigs after challenge with zearalenone (ZEA)a
ZEA x MC
Weight gain, g/day
Feed intake, g/day
Apparent total tract digestibility coefficient, %
The effects of montmorillonite clay on performance and reproductive tract characteristics of growing gilts after challenge with zearalenone (ZEA)
ZEA x MC
Weight gain, g/day
Feed intake, g/day
Environmental impact of feeding clays to pigs
Feeding clay to pigs may help to minimize the impact of swine production on the environment. Shurson et al.  and Poulsen and Oksbjerg  reported that the amount of nitrogen excreted in feces was significantly higher while urinary nitrogen excretion was lower in pigs fed zeolites. As urinary nitrogen is more volatile than fecal nitrogen, this change in excretion pattern would tend to reduce the amount of nitrogen lost to the environment from a swine operation.
Volatile fatty acids are responsible for a significant proportion of the odor arising from swine operations. Chen et al.  reported that fecal propionic acid, butyric acid and acetic acid were significantly reduced in pigs fed Biotite. They also reported reductions in fecal ammonia levels.
Livestock production can make good use of resources, which contributes high quality nutrient to the human diet . Dietary supplementation with clays has been shown to improve weight gain and feed conversion in pigs. Where improvements in performance have been noted, one of the most likely explanations for the improvement is the fact that dietary clay supplementation increases nutrient digestibility. Clays reduce the speed of passage of feed along the digestive tract which allows more time for digestion. Feeding clay minerals also causes morphological changes in the intestinal mucosa such as an increase in villus height and an increase in the villus height to crypt depth ratio. An increase in villus height increases the surface area for nutrient absorption thus increasing nutrient digestibility. Several studies have indicated that feeding clay reduces the incidence, severity and duration of diarrhea in pigs. The mechanism for the reduction in diarrhea is likely due to increases in the numbers of Bifidobacteria and Lactobacillus and decreases in the numbers of Clostridium and E. coli in the small intestine of pigs fed clay. In addition, the numbers of pigs born alive and weaned, birth weight and weaning weight have been shown to be higher for sows fed clay. Several studies have indicated that clays can mitigate the effects of mycotoxins. Clays can be used as an alternative to antibiotics for the prevention of diarrheal diseases and the enhancement of pig growth and reproduction during crucial periods.
The authors would like to acknowledge Jae Won Park and Seung Cheol Kim, Swine Nutrition and Feed Technology (SNFT) members for their valuable contribution towards the collection and interpretation of data.
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Barton MD. Antibiotic use in animal feed and its impact on human health. Nutr Res Rev. 2000;13:279–99.View ArticlePubMedGoogle Scholar
- Turner JL, Pas S, Dritz SS, Minton JE. Review: Alternatives to conventional antimicrobials in swine diets. Prof Anim Sci. 2001;25:217–26.Google Scholar
- Thacker PA. Alternatives to antibiotics as growth promoters for use in swine production: A review. J Anim Sci Biotechnol. 2013;4:35.PubMed CentralView ArticlePubMedGoogle Scholar
- Vondruskova H, Slamova R, Trckova M, Zraly Z, Pavli I. Alternatives to antibiotic growth promotors in prevention of diarrhea in weaned piglets: A review. Vet Med. 2010;55:199–224.Google Scholar
- Song M, Liu Y, Soares JA, Che TM, Osuna O, Maddox CW, et al. Dietary clays alleviate diarrhea of weaned pigs. J Anim Sci. 2012;90:345–60.View ArticlePubMedGoogle Scholar
- Trckova M, Vondruskova H, Zraly Z, Alexa P, Hamrik J, Kummer V, et al. The effect of kaolin feeding on efficiency, health status and course of diarrhoeal infections caused by enterotoxigenic Escherichia coli strains in weaned piglets. Vet Med. 2009;54:47–63.Google Scholar
- Prvulovic D, Jovanovic-Galovicc A, Stanic B, Popovic M, Grubor-Lajsic. Effects of clinoptilolite supplement in pig diets on performance and serum parameters. Czech J Anim Sci. 2007;52:159–64.Google Scholar
- Chen YJ, Kwon OS, Min B, Son KS, Cho JH, Hong JW, et al. The effects of dietary Biotite V supplementation as an alternative substance to antibiotics in growing pigs. Asian-Aust J Anim Sci. 2005;18:1642–5.View ArticleGoogle Scholar
- Chen YJ, Kwon OS, Min BJ, Shon KS, Cho JH, Kim IH. The effects of dietary Biotite V supplementation on growth performance, nutrients digestibility and fecal noxious gas content in finishing pigs. Asian-Aust J Anim Sci. 2005;18:1147–52.View ArticleGoogle Scholar
- Almeida JAS. Identification of mechanisms of beneficial effects of dietary clays in pigs and chicks during an enteric infection. PhD Thesis, University of Illinois, Champaign, Illinois 2013.Google Scholar
- Phillips TD, Marroquin CA, Deng Y, Taylor JF, Hallmark CT, Johnson NM. In vitro and in vivo characterization of mycotoxin-binding additives used for animal feeds in Mexico. Food Addit Contam A. 2009;26:733–43.View ArticleGoogle Scholar
- Phillips TD. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol Sci. 1999;52:118–26.View ArticlePubMedGoogle Scholar
- Lindemann MD, Blodgett DJ, Kornegay ET, Schurig GG. Potential ameliorators of aflatoxicosis in weanling/growing swine. J Anim Sci. 1993;71:171–8.PubMedGoogle Scholar
- Schell TC, Lindemann MD, Kornegay ET, Blodgett DJ, Doerr JA. Effectiveness of different types of clay for reducing the detrimental effects of aflatoxin contaminated diets on performance and serum profiles of weanling pigs. J Anim Sci. 1993;71:1226–31.PubMedGoogle Scholar
- Schell TC, Lindemann MD, Kornegay ET, Blodgett DJ. Effects of feeding aflatoxin-contaminated diets with and without clay to weanling and growing pigs on performance, liver function, and mineral metabolism. J Anim Sci. 1993;71:1209–18.PubMedGoogle Scholar
- Nguyen QT, Ogle B, Pettersson H. Efficacy of bentonite clay in ameliorating aflatoxicosis in piglets fed aflatoxin contaminated diets. Trop Anim Health Prod. 2008;40:649–56.View ArticleGoogle Scholar
- Ramos AJ, Hernandez E. Prevention of aflatoxicosis in farm animal by means of hydrated sodium calcium aluminosilicate addition to feedstuffs: A review. Anim Feed Sci Technol. 1997;65:197–206.View ArticleGoogle Scholar
- Lin XL, Xu ZR, Zou XT, Wang F, Yan XH, Jiang JF. Effects of montmorillonite nanocomposite on mercury residues in growing/finishing pigs. Asian-Aust J Anim Sci. 2004;17:1434–7.View ArticleGoogle Scholar
- Ramos AJ, Fink-Gremmels J, Hernandez E. Prevention of toxic effects of mycotoxins by means of nonnutritive adsorbent compounds. J Food Prot. 1996;59:631–41.Google Scholar
- Yu DY, Li XL, Li WF. Effect of montmorillonite superfine composite on growth performance and tissue lead level in pigs. Biol Trace Elem Res. 2008;125:229–35.View ArticlePubMedGoogle Scholar
- Yu DY, Xu ZR, Yang XG. Effects of lead and particulate montmorillonite on growth performance, hormone and organ weight in pigs. Asian-Aust J Anim Sci. 2005;18:1775–9.View ArticleGoogle Scholar
- Fokas P, Zervas G, Fegeros K, Zoiopoulos P. Assessment of Pb retention coefficient and nutrient utilization in growing pigs diets with added clinoptilolite. Anim Feed Sci Technol. 2004;117:121–9.View ArticleGoogle Scholar
- Yu DY, Song WH, Zhou B, Li WF. Assessment of Cu (II)-bearing montmorillonite on Cd adsorption. Biol Trace Elem Res. 2009;130:185–92.View ArticlePubMedGoogle Scholar
- Xu ZR, Han XY, Wang YZ. Effects of growth and cadmium residues from feeding cadmium-added diets with and without montmorillonite nanocomposite to growing pigs. Vet Hum Toxicol. 2004;46:238–41.PubMedGoogle Scholar
- Knezevich DL, Tadic V. Decontamination with clay or alcoholate of pigs percutaneously poisoned with VX and soman (in Croatian). Vojnosanit Pregl. 1994;51:488–91.Google Scholar
- Duan QW, Li JT, Gong LM, Wu H, Zhang LY. Effects of graded levels of montmorillonite on performance, hematological parameters and bone mineralization in weaned pigs. Asian Aust J Anim Sci. 2013;26:1614–21.View ArticleGoogle Scholar
- Li J, Kim IH. Effects of dietary supplementation of sericite on growth performance, nutrient digestibility, blood profiles and fecal microflora shedding in growing pigs. Anim Feed Sci Technol. 2013;184:100–4.View ArticleGoogle Scholar
- Yan L, Lee JH, Meng QW, Kim IH. Evaluation of the Anion® supplementation on growth performance, nutrient digestibility, blood characteristics and faecal noxious gas content in weaning pigs. J Appl Anim Res. 2011;39:36–40.View ArticleGoogle Scholar
- Papaioannou DS, Kyriakis CS, Alexopoulos C, Tzika ED, Polizopoulou ZS, Kyriakis SC. A field study on the effect of dietary use of a clinoptilolite-rich tuff, alone or in combination with certain antimicrobials on the health status and performance of weaned, growing and finishing pigs. Res Vet Sci. 2004;76:19–29.View ArticlePubMedGoogle Scholar
- Alexopoulos C, Papaioannou DS, Fortomaris P, Kyriakis CS, Tserveni-Goussi A, Yannakopoulos A, et al. Experimental study of the effect of in-feed administration of a clinoptilolite-rich tuff on certain biochemical and hematological parameters of growing and fattening pigs. Livest Sci. 2007;111:230–41.View ArticleGoogle Scholar
- Pond WG, Yen JT, Varel VH. Response of growing pigs to dietary copper and clinoptilolite supplementation. Nutr Rep. 1988;37:795–803.Google Scholar
- Xia MS, Hu CH, Xu ZR. Effects of copper bearing montmorillonite on the growth performance, intestinal microflora and morphology of weanling pigs. Anim Feed Sci Technol. 2005;118:307–17.View ArticleGoogle Scholar
- Thacker PA. Performance of growing-finishing pigs fed diets containing graded levels of biotite, an aluminosilicate clay. Asian-Aust J Anim Sci. 2003;16:1666–72.View ArticleGoogle Scholar
- Yan L, Han DL, Meng QW, Lee JH, Park CJ, Kim IH. Effects of anion supplementation on growth performance, nutrient digestibility, meat quality and fecal noxious gas content in growing-finishing pigs. Asian-Aust J Anim. 2010;23:1073–9.View ArticleGoogle Scholar
- Poulsen HD, Oksbjerg N. Effect of dietary inclusion of a zeolite (Clinoptilolite) on performance and protein-metabolism of young growing pigs. Anim Feed Sci Technol. 1995;53:297–303.View ArticleGoogle Scholar
- Shurson GC, Ku PK, Miller ER, Yokoyama MT. Effects of zeolite or clinoptililite in diets of growing swine. J Anim Sci. 1984;59:1536–45.PubMedGoogle Scholar
- Parisini P, Martelli G, Sardi L, Escribano F. Protein and energy retention in pigs fed diets containing sepiolite. Anim Feed Sci Technol. 1999;79:155–62.View ArticleGoogle Scholar
- Abranches J, Almeida S, Liu Y, Song M, Lee JJ, Gaskins HR, et al. Escherichia coli challenge and one type of smectite alter intestinal barrier of pigs. J Anim Sci Biotechnol. 2013;4:52.View ArticleGoogle Scholar
- Han YK, Thacker PA. Effects of l-carnitine, selenium-enriched yeast, jujube fruit and Hwangto (Red Clay) supplementation on performance and carcass measurements of finishing pigs. Asian-Aust J Anim Sci. 2006;19:217–23.View ArticleGoogle Scholar
- Cabezas MJ, Salvador D, Dinisteraa JV. Stabilization-activation of pancreatic-enzymes adsorbed on to a sepolite clay. J Chem Technol Biotechnol. 1991;52:265–74.View ArticleGoogle Scholar
- Xia MS, Hu CH, Xu ZR, Ye Y, Zhou YH, Xiong L. Effects of copper-bearing montmorillonite (Cu-MMT) on Esherichia coli and diarrhea on weanling pigs. Asian-Aust J Anim Sci. 2004;17:1712–6.View ArticleGoogle Scholar
- Wang JP, Chi F, Kim IH. Effects of montmorillonite clay on growth performance, nutrient digestibility, vulva size, faecal microflora, and oxidative stress in weaning gilts challenged with zearalenone. Anim Feed Sci Technol. 2012;178:158–66.View ArticleGoogle Scholar
- Stojic V, Gagrčin M, Kirovski D, Fratrić N. The effect of clinoptilolite based mineral adorber on colostrum immunoglobulin G adsorption in newborn piglets. Acta Vet. 1998;48:19–26.Google Scholar
- Papaioannou DS, Kyriakis SC, Papasteriadis A, Roumbies N, Yannakopoulos A, Alexopoulos C. A field study on the effect of in-feed inclusion of a natural zeolite (clinoptilolite) on health status and performance of sows/gilts and their litters. Res Vet Sci. 2002;72:51–9.View ArticlePubMedGoogle Scholar
- Kyriakis SC, Papaioannou DS, Alexopoulos C, Polizopoulou Z, Tzika ED, Kyriakis CS. Experimental studies on safety and efficacy of the dietary use of a clinoptilolite-rich tuff in sows: A review of recent research in Greece. Micoporous Mesoporous Materials. 2002;51:65–74.View ArticleGoogle Scholar
- Jiang SZ, Yang ZB, Yang WR, Yao BQ, Zhao H, Liu FX, et al. Effects of feeding purified Zearalenone contaminated diets with or without clay enterosorbent on growth, nutrient availability, and genital organs in post-weaning female pigs. Asian-Aust J Anim Sci. 2010;23:74–81.View ArticleGoogle Scholar
- Jiang SZ, Yang ZB, Yang WR, Gao J, Liu FX, Chen CC, et al. Physiopathological effects of zearalenone in post-weaning female piglets with or without montmorillonite clay adsorbent. Livest Sci. 2010;131:130–6.View ArticleGoogle Scholar
- Mohana Devi S, Balachandar V, Lee SI, Kim IH. An outline of meat consumption in the Indian population – A pilot review. Korean J Food Sci An. 2014;34(4):507–15.View ArticleGoogle Scholar