Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol

Table 1 Effects of ovarian progesterone (P4) and intrauterine infusion of interferon tau (IFNT), prostaglandins (PGs) or cortisol on elongation- and implantation-related genes expressed in the endometrial epithelia of the ovine uterus ¹

Gene symbol	P4	IFNT	PGs²	Cortisol
Transport of glucose
SLC2A1	↑	+	+	+
SLC2A5	n.d.	n.e.	+	+
SLC2A12	n.d.	+	n.e. or +	+
SLC5A1	↑	+	n.e. or +	+
SLC5A11	↑	+	n.e. or +	n.e.
Transport of amino acids
SLC1A5	n.d.	n.d.	+	+
SLC7A2	↑	+	n.e.	n.e.
Cell proliferation, migration and (or) attachment
GRP	↑	+	+	+
IGFBP1	↑	+	++	n.e.
LGALS15	↑	++	++	++
SPP1	↑	+	n.d.	++
Proteases and their inhibitors
CTSL1	↑	++	n.e. or +	+
CST3	↑	+	n.e. or +	n.e.
CST6		+	n.e.	+
Enzymes
HSD11B1	↑	+	++	+
PTGS2	↑	n.e. (+ activity)	n.e. (+ activity)	n.e. (+ activity)

¹Effect of hormone or factor denoted as induction (↑), stimulation (+ or ++), no effect (n.e.), decrease (-) or not determined (n.d.). ²Summary data for infusion of PGE2, PGF2α, or PGI2 [40].

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