Pathways | Target genes | OF-EVs | UF-EVs | ||
---|---|---|---|---|---|
Exclusive miRNAs (11) | Up-regulated miRNA (1) | Exclusive miRNAs (59) | Up-regulated miRNAs (19) | ||
Endocytosis | Total | 59 genes | 14 genes | 177 genes | 141 genes |
Exclusively modulated | 3 (FAM21A, LOC616942, HSPA1A) | 1 (AP2A2) | 42 (CCR5, CAPZA2, ARPC1B, ARF3, VPS25, MVB12A, AP2M1, ARPC2, VPS28, VTA1, BOLA, RAB4A, HGS, SNX6, CAV3, SNF8, CHMP6, STAMBP, AP2S1, USP8, RAB5A, SNX4, TSG101, CBLC, RAB8A, AP2A1, EHD4, RAB11FIP2, VPS26B, PRKCI, TFRC, CLTB, CXCR4, GRK5, HSPA8, IGF2R, SPG21, PIP5K1B, WASHC5, GRK4, ARAP1, IZUMO1R) | 14 (VPS29, RAB11B, CHMP2B, JSP1, FOLR2, CYTH2, SPART, SNX3, ACAP2, BoLA, PSD, FGFR4, ARRB2, FOLR3) | |
Ras signaling | Total | 56 genes | 12 genes | 0 genes | 145 genes |
Exclusively modulated | 1 (PLA2G12B) | 1 (KSR) | 30 (PLA2G2D1, STK4, PLA2G4A, FGF18, PAK4, RAB5A, IGF1, RRAS2, RAC3, RASAL3, MAP2K1, RASGRP1, CALM, FGF20, RIN1, GNB3, PLA2G4F, FGF16, EXOC2, PAK2, CALM2, IKBKB, IKBKG, VEGFB, VEGFC, PIK3R2, LOC615045, PLA2G2C, LOC786717, LOC789148) | 14 (PLA1A, PLA2G16, PRKCG, INS, FGFR4, TBK1, EPHA2, PIK3CB, GNG2, PLCG1, PRKCA, RASA1, LOC521224, SHC2) | |
Insulin signaling | Total | 8 genes | 35 genes | 101 genes | 87 genes |
Exclusively modulated | 1 (PDPK) | 0 | 23 (HK1, RHEB, PPP1CA, PKLR, PRKAR1A, EIF4EBP1, LIPE, PTPN1, PRKAA1, MAP2K1, CALM, INPP5J, ACACB, PPP1R3A, PRKCI, CALM2, IKBKB, PIK3R2, PCK1, MTOR, PHKA1, HK2, PRKAG2) | 9 (FLOT1, INS, PHKA2, GYS2, RPS6KB2, PIK3CB, G6PC3, TSC2, SHC2) | |
Wnt signaling | Total | 0 genes | 9 genes | 118 genes | 97 genes |
Exclusively modulated | 0 | 0 | 30 (WNT2, PRICKLE3, SFRP2, MYC, SFRP4, WIF1, CTNNB1, DAAM1, DKK2, PPARD, MAPK10, CSNK1B, RAC3, FZD1, PORCN, NFATC4, ROR2, PLCB4, RNF43, AXIN1, AXIN2, SIAH1, GPC4, PPP3R1, CSNK2A1, CSNK1A1, APC2, RYK, EP300, CTBP1) | 8 (WNT16, CAMK2D, RSPO3, WNT10A, CREBBP, PRKCG, PRKCA, LOC780968) | |
Regulation of actin cytoskeleton | Total | 51 genes | 0 genes | 153 genes | 126 genes |
Exclusively modulated | 1 (MYL2) | 0 | 30 (ARPC1B, PFN1, GSN, ARPC2, PPP1CA, ACTN1, FGF18, PAK4, PFN3, MYLK2, RRAS2, RAC3, ITGB7, MAP2K1, FGF20, DIAPH3, FGF16, CYFIP1, PAK2, LPAR1, CXCR4, ITGAV, ITGB1, PIK3R2, ITGA4, ITGB2, APC2, PIP5K1B, ARHGEF1, PPP1R12C) | 4 (INS, FGFR4, ITGB4, PIK3CB) |