Fig. 1From: Exploring the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shiga toxin-producing E. coli challenged weaned pigletsTimeline of the bLF microbiome trial and F18+ STEC challenge in vivo. In both trials, bovine lactoferrin (bLF) was administered orally twice a day (for a total of 500 mg/d) for 10 consecutive days. To study the gut microbiome different samples were taken: faecal swabs were collected during the experiments, as indicated in the timeline, and mucosal scrapings and intestinal content of both ileum and colon were sampled upon euthanasia, indicated by †. The challenge infection with an F18+ STEC strain (F107/86) was carried out on D0 and D1. Blood and faeces were collected on different timepoint to determine effect of bLF on F18-specific immune responses and faecal shedding. bLF: bovine lactoferrin, STEC: Shiga toxin-producing E. coliBack to article page