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Table 5 Effects of ATRA on the concentrations of cytokines and sIgA in jejunal mucosa of piglets challenged with TGEV

From: All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

Items

Control

TGEV

TGEV + ATRA5

TGEV + ATRA15

P-value

IL-1β, pg/mg prot

12.86 ± 0.92a

16.53 ± 0.70b

12.37 ± 1.35a

14.62 ± 0.62ab

0.017

IL-6, pg/mg prot

196.40 ± 20.35

220.65 ± 9.08

178.30 ± 21.87

203.46 ± 12.86

0.357

IL-8, pg/mg prot

112.38 ± 6.82a

152.20 ± 6.52b

114.89 ± 10.65a

118.93 ± 5.75a

0.003

IL-10, pg/mg prot

36.90 ± 3.16b

23.70 ± 2.12a

33.71 ± 2.58b

34.78 ± 2.18b

0.005

TNF-α, pg/mg prot

93.51 ± 7.62

103.41 ± 5.54

84.75 ± 7.47

96.64 ± 5.06

0.261

sIgA, µg/mg prot

19.17 ± 1.08b

13.77 ± 0.84a

18.51 ± 1.41b

18.10 ± 1.32ab

0.013

  1. IL Interleukin, TNF-α Tumor necrosis factor-α, sIgA Secretion immunoglobulin A. Data are presented as mean ± SE. a,bValues in the same row with different superscripts letters are significantly different (P < 0.05)