Skip to main content

Table 2 Distal colon digesta metabolites that differed among dietary treatments

From: Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic E. coli

Metabolite

Fold change1

FDR2

VIP3

LOW4 vs. CAR5, d 5 post-inoculation

 Tocopherol acetate

0.47

0.186

1.92

 Arabitol

2.03

0.186

1.99

 Octadecylglycerol

3.32

0.186

1.97

 2-Hydroxyglutaric acid

3.62

0.186

2.09

 2-Hydroxyvaleric acid

11.32

0.186

1.93

HIGH6 vs. CAR, d 5 post-inoculation

 Phosphate

0.32

0.164

1.60

 Arabitol

1.99

1.590

1.64

 Conduritol-beta-epoxide

2.02

0.164

1.56

 Ferulic acid

2.19

0.140

1.80

 Cellobiose

2.28

0.188

1.52

 Proline

2.36

0.164

1.58

 Docosahexaenoic acid

2.43

0.140

1.77

 Cysteine

2.97

0.140

1.74

 Octadecylglycerol

3.31

1.729

1.56

 Maltotriose

4.85

0.156

1.66

 Indole-3-acetate

7.97

0.164

1.57

 Tranexamic acid

12.06

0.140

1.91

CON7 vs. LOW, d 11 post-inoculation

 Tranexamic acid

0.16

0.159

1.73

 Hydroquinone

0.19

0.197

1.55

 Urea

0.31

0.190

1.61

 2-Hydroxyhexanoic acid

0.35

0.190

1.60

 3,6-Anhydro-D-glucose

0.39

0.105

1.96

 Adenosine

0.40

0.138

1.82

 3,6-Anhydro-D-galactose

0.44

0.159

1.76

 Fructose

0.44

0.182

1.66

 Glucose

0.47

0.167

1.70

 Myo-inositol

0.48

0.161

1.72

 Pimelic acid

2.01

0.159

1.76

 Nonadecanoic acid

2.37

0.138

1.84

 Heptadecanoic acid

2.57

0.105

1.92

 Pentadecanoic acid

2.58

0.105

1.94

 Isopentadecanoic acid

2.66

0.052

2.15

 Isoheptadecanoic acid

3.33

0.159

1.74

 Uric acid

3.35

0.122

1.88

LOW vs. HIGH, d 11 post-inoculation

 Phytanic acid

0.50

0.147

2.42

LOW vs. CAR, d 11 post-inoculation

 6-Deoxyglucose

2.09

0.185

1.79

 Adenosine

3.20

0.185

1.76

 Fructose

4.26

0.065

1.98

HIGH vs. CAR, d 11 post-inoculation

 Fructose-6-phosphate

0.21

0.168

1.75

 Xanthosine

2.02

0.170

1.67

 Aminomalonate

2.03

0.168

1.74

 Pyruvic acid

2.14

0.105

1.89

 6-Deoxyglucose

2.31

0.170

1.66

 Azelaic acid

2.50

0.053

2.02

 3-Hydroxybutyric acid

2.62

0.170

1.68

 Arabitol

3.12

0.168

1.76

 2-Hydroxyhexanoic acid

9.76

0.170

0.89

  1. 1Fold change values less than 1 indicate that the differential metabolites were reduced in the LOW compared with CAR; HIGH compared with CAR; CON compared with LOW; or LOW compared with HIGH, respectively
  2. 2FDR = False discovery rate
  3. 3VIP = Variable importance in the projection
  4. 4LOW = Control diet supplemented with 10 mg/kg of oligosaccharide-based polymer
  5. 5CAR = Control diet supplemented with 50 mg/kg of carbadox
  6. 6HIGH = Control diet supplemented with 20 mg/kg of oligosaccharide-based polymer
  7. 7CON = Basal nursery diet (control)