Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic E. coli

Table 1 Serum metabolites that differed among dietary treatments

Metabolite	Fold change¹	FDR²	VIP³
CON⁴ vs. CAR⁵, d 5 post-inoculation
Inosine	0.41	0.089	1.67
Glycerol	2.09	0.056	1.83
Galactonic acid	2.26	0.087	1.69
Propylene glycol	2.51	0.139	1.50
LOW⁶ vs. CAR, d 5 post-inoculation
Inosine	0.33	0.057	2.02
Guanosine	0.49	0.062	1.88
Glycerol	3.39	0.103	1.69
HIGH⁷ vs. CAR, d 5 post-inoculation
p-Tolyl glucuronide	0.47	0.106	1.73
Inosine	0.47	0.132	1.65
Glycerol	2.28	0.050	2.07
Palmitoleic acid	2.45	0.179	1.50
Propylene glycol	2.82	0.106	1.75
CON vs. CAR, d 11 post-inoculation
Glycerol	0.33	0.146	1.76
Inositol-4-monophosphate	0.48	0.168	1.67
Chenodeoxycholic acid	3.01	0.117	1.90
HIGH vs. CAR, d 11 post-inoculation
Chenodeoxycholic acid	0.39	0.197	2.11

¹Fold change values less than 1 indicate that the differential metabolites were reduced in the CON compared with CAR; LOW compared with CAR; or HIGH compared with CAR, respectively
²FDR = False discovery rate
³VIP = Variable importance in the projection
⁴CON = Basal nursery diet (control)
⁵CAR = Control diet supplemented with 50 mg/kg of carbadox
⁶LOW = Control diet supplemented with 10 mg/kg of oligosaccharide-based polymer
⁷HIGH = Control diet supplemented with 20 mg/kg of oligosaccharide-based polymer

ISSN: 2049-1891