Fig. 1

Overview of porcine methylome and transcriptome studies. A A histogram of mean methylation difference between PA and CN embryos in chromosome 11 (chr11) plotted against count (square root transformed y-axis) of methylated regions (MRs; satisfying distance between CpGs < 300 bp, > 10 CpGs, and mean methylation difference > 0.2, as defined in Methods). Differentially methylated regions (DMRs; FDR < 0.05) among MRs are overlaid. B DMRs between PA and CN embryos and expression patterns identified in chr11. Gene expression levels from RNA-seq is presented in transcripts per million (TPM). DMR (mat +), maternally hypermethylated DMR; DMR (pat +), paternally hypermethylated DMR; exp, expression; Known, known imprinted gene