Fig. 2From: Whole-genome transcriptome and DNA methylation dynamics of pre-implantation embryos reveal progression of embryonic genome activation in buffaloesThe DNA methylome landscape during buffalo PED. A Global CpG methylation levels at each developmental stage. B The trend of average CpG methylation levels from 5Â kb upstream to 5Â kb downstream of the gene bodies. C The distribution percentage of CpG with different methylation levels at each developmental stage. D The numbers of DMRs in consecutive developmental stages during buffalo PED. E The distribution of DMRs across the global genome in several pairwise comparisons. a, GV oocyte vs. MII oocyte; b, MII oocyte vs. Zygote; c, Zygote vs. 2-cell; d, 2-cell vs. 4cell; e, 4-cell vs. 8-cell; f, 8-cell vs. 16-cell; g, 16-cell vs. Morula; h, Morula vs. ICM. F The trend of average CpG methylation levels with different expression levels (high, medium, low and no expression) using the 8-cell stage as an exampleBack to article page