Fig. 5

Comparison of the molecular mechanism of coarse wool follicle morphogenesis between ALC and coarse wool lamb breeds. A Analysis of top GO terms and KEGG pathways (Metascape database: http://www.metascape.org/) by using up and down-regulated differentially expressed genes in ALC wool lamb skin. −log10 of the P value as were taken at the X-axis for enrichment analysis. The up-regulated differentially expressed genes in embryos are shown in red bars, while the blue bars indicate the at-birth or adulthood stage. The numbers represent the number of genes enriched in each term. B The overlap of up-regulated DEGs in hair follicle morphogenesis process between ALC wool lambs and coarse wool lamb breeds. C The overlap of up-regulated DEGs in Wnt signal pathway between ALC wool lambs and coarse wool lamb breeds. D Expression analysis of candidate genes among coarse and fine wool breeds at different developmental stages. ^*0.01 < P < 0.05, ^**P < 0.01, ^***P < 0.001. E Analysis of key protein interactions network by using online tool (GeneMANIA: http://genemania.org/)