Fig. 6

The circos plot of multi-omics significant signatures. The four Manhattan plots with grey backgrounds from outside to inside indicate the significant signatures identified by GWAS, cis-eQTL Mapping, and TWAS. The results of GWAS-eQTL colocalization by coloc or SMR are shown between GWAS and eQTL Manhattan plot, which were labeled with gene name and tissue abbreviation after a colon (A: adipose, L: liver, M: muscle). The gene label colors and the dot colors of the eQTL Manhattan plot with green, hot pink, and purple represents adipose, liver, and muscle, respectively