Table 2 DNA methylation biomarkers associated with aging traits in different species
From: Harnessing male germline epigenomics for the genetic improvement in cattle
Epigenetic biomarker | Aging trait | Tissue | Species | Reference |
|---|---|---|---|---|
DENND1A, SIRT1 | Aging | Blood and oocyte | Cattle | [90] |
NKX6-1, ISL1, LHX1, MAP4K3, MCF2L and SMAD7 | Tail hair | [91] | ||
Promoter regions of key transcription factors | Exceptional longevity | Wing | Bat | [92] |
PRC2, Hox, EN1 | Aging | Blood, bladder, frontal cortex, kidney, liver, and lung | Pig | [93] |
P2RXL1, SCGN, EDARADD, IPO8 and NHLRC1 | Lifespan | Blood | Human | [94] |
Aqp1, Npy and Adcyap1r1 | Aging | Adipose, blood, liver, kidney, muscle, and lung | Mouse | [95] |
FANCL, MAF, ZNF608, PBX3, PLCB1, NEUROD1 and BARHL2 | Aging | Blood | Zebra | [86] |
ZFHX3, PGM1, SATB2 and KNC4 | Age | Blood | Elephant | [82] |
Igfbp3 and DNMT3L | Health | Jejunum, ileum, breast muscle and spleen | Chicken | [78] |
SLC12A5, HECTD2, NEUROD1 and FOXG1 | Age | Blood | Cat | [96] |
NPAS3, STC1, HOXC4 and LOC117200810 | Age | Blood and skin | Whale | [97] |
ANK1, EVX2 and UNC5D | Dolphin | |||
FGF8, PAX6, PAX5 and HOXC4 | Age | Blood and ear | Sheep | [98] |
TNRC6A and LHFPL4 | Age | Ear | Deer and goat | [99] |
LHFPL4, BARHL2 and PLD5 | Age | Blood, liver and skin | Rat | [100] |