Table 1 Sperm epigenetic biomarkers associated with fertility from our results and other studies
From: Harnessing male germline epigenomics for the genetic improvement in cattle
Epigenetic type | Epigenetic biomarker | Tissue | Fertility trait | Reference | |
|---|---|---|---|---|---|
DNA methylation | BUB1, CATSPER4, DMKN, ELN, INSL3, LAMB2, PATL2, PLXNB1, TMEM235 | Holstein bull sperm | Number of motile sperm per ejaculate | Our own unpublished data | |
CYP26B1, SNAI2, PLD1, LZTR, MAPK8IP3, NME3, LIG3, POU5F1, GHSR, SIRT1, LRGUK, RESP18, STX5 | Buffalo bull sperm | Cattle fertility | [73] | ||
Crisp2, Hgf, Zfp36l1 | Holstein bull sperm | Cattle fertility (SCR) | [74] | ||
SPEF2 | Holstein bull sperm | Cattle sperm motility | [75] | ||
HSPA1L, ACTN1, PSMD3, CSRP2 | Holstein bull sperm | Sperm quality/female reproductive traits | [63] | ||
EEFSEC, CYP26B1, SNAI2, PLD1, LZTR, MAPK8IP3, NME3, LIG3, POU5F1, GHSR, SIRT1, LRGUK, RESP18, STX5 | Bubalus bubalis | Cattle fertility | [76] | ||
SAMD5, PDE5A | Holstein bull sperm | Cattle fertility (SCR) | [46] | ||
SFRP1STXBP4, BCR, PSMG4, ARSG, ATP11A, RXRA | Holstein bull sperm | Cattle fertility | [62] | ||
LBX1 (upstream regions), NPAS1 (exons), SORCS2 (introns), PLXNB2 (intron–exon junctions), ATG7 (3’UTRs) | Montbéliarde bulls sperm | Cattle fertility | [61] | ||
Histone methylation | H3K4me2, H3K27me3 | Buffalo | Cattle fertility | [76] | |
H3K27me3, H3K27ac | Holstein bull sperm | Cattle fertility | [77] | ||
Non-coding RNA | lncRNA | TCONS_00041733 | Holstein bull sperm | Cattle sperm motility | [78] |
COX7A2, COX6B2, TRIM37, PRM2, INHBA, ERBB4, SDHA, ATP6VOA2, FGF9, TCF21 | Wandong bull testes | Cattle spermatogenesis | [79] | ||
miRNA | miR-93, miR-106b, miR-100, miR-122, miR-184, miR-486-5p, miR-2285n | Holstein bull sperm | Cattle sperm motility | [80] | |
miR-15a, miR29 | Holstein bull sperm | Cattle fertility | [81] | ||
miR-33b, miR-126-5p, miR-205, miR-505, miR-532, miR-500, miR-542-5p, miR-216b, miR-339a | Aberdeen Angus | Cattle fertility | [82] | ||
siRNA | DICER, DGCR8 | Mouse male sperm | Male fertility | [83] | |
piRNA | piR-31068, piR-31925, piR-43771, piR-43773, piR-30198 | Chinese male sperm | Male fertility | [84] | |
tsRNA | tsRNAGln−TTGs | Pig male sperm | Male fertility | [85] | |
rRNA | RPL23, RPL27A, RPS18, RPL6, RPL36AL, RPL37 | Human sperm | Male spermatogenesis | [86] | |
Nucleosome positioning | CTCF | Human sperm | Male fertility | [87] | |