Table 1 Summary of genes associated with metabolite synthesis, metabolism and regulation in the mGWAS

Amino acids

 AASS

1

23,028,514

trans-3-Aminocyclopentane-1-carboxylic acid

G/A

5.38E−11

Aminoadipate-semialdehyde synthase

a2192

1

23,005,471

Homoarginine

A/T

1.04E−11

a6139

 PYCR3

2

148,895,024

D-2-Aminoadipic acid

C/T

2.68E−13

Pyrroline-5-Carboxylate Reductase 3

a2916

 FDFT1

3

107,355,672

L-2-Amino-6-oxoheptanedioate

A/G

6.92E−15

Farnesyl-Diphosphate Farnesyltransferase 1

a6166

 MSRA

3

106,645,100

L-2-Amino-6-oxoheptanedioate

A/G

2.76E−10

Methionine Sulfoxide Reductase A

a6166

3

107,535,427

N-oleoyl threonine

C/T

7.75E−12

a18373

 TDH

3

107,175,865

Glycine

T/C

1.64E−14

L-Threonine Dehydrogenase (Pseudogene)

b23

 MTMR4

4

14,104,422

L-Serine

C/T

3.78E−08

Myotubularin Related Protein 4

c356

 GOT1

6

23,099,727

N6-Methyl-L-lysine

T/C

2.52E−19

Glutamic-Oxaloacetic Transaminase 1

a4060

 HOGA1

6

23,275,981

N6-Methyl-L-lysine

A/G

3.83E−20

4-Hydroxy-2-Oxoglutarate Aldolase 1

a4060

Lipids

 CD36

1

11,301,220

Cer 36:3

T/C

9.05E−13

Cluster of differentiation 36

a26248

1

11,358,208

Cer-NS d36:3

G/A

1.33E−18

b21105

1

11,370,522

Cer-NP t19:1/14:1

A/C

4.19E−14

b21776

1

11,301,220

Cer 36:3

T/C

1.31E−12

c11086

 RORA

1

121,625,308

17α,21-Dihydroxypregnenolone

A/G

1.93E−08

RAR Related Orphan Receptor A

a16236

 ABCB1

2

20,748,311

PA 37:10

G/A

1.87E−20

ATP Binding Cassette Subfamily B Member 1

d14475

2

20,748,311

1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine (PC(16:0/18:1(9Z)))

G/A

7.58E−09

d14771

 CUBN

2

19,974,415

(3S,3'R,5R,6R)-7',8'-Didehydro-3,6-epoxy-5,6-dihydro-beta, beta-carotene-3',5-diol

C/T

4.11E−10

Cubilin

d13798

2

19,974,415

PA 37:10

C/T

3.19E−15

d14475

 HACD2

2

19,684,787

PA 37:10

T/A

4.30E−12

3-Hydroxyacyl-CoA Dehydratase 2

d14475

 OLAH

2

20,632,976

PA 37:10

A/G

8.80E−24

Oleoyl-ACP Hydrolase

d14475

2

20,812,193

PS 36:2

C/A

8.98E−09

d14886

 MTMR9

3

107,155,447

PC 35:3

C/T

2.24E−09

Myotubularin Related Protein 9

b24244

 SNX17

3

104,426,364

SM 34:0

G/T

7.63E−09

Sorting Nexin 17

c14637

 HPGDS

4

37,173,242

Corticosterone

A/C

4.43E−12

Hematopoietic Prostaglandin D Synthase

d9959

 GALC

5

43,096,098

Phosphatidylethanolamine 18:2–18:2

T/C

3.66E−10

Galactosylceramidase

b23510

 NPC2

5

38,143,267

Plasmenyl-PC 34:2

G/A

3.75E−08

NPC Intracellular Cholesterol Transporter 2

a32135

 CYP2C23a-ALOX5

6

18,456,793

8(R)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid (8R-HETE)

G/A

9.44E−12

Cyclooxygenases, and cytochrome P450s-lipoxygenases

d9222

 AGAP1

7

5,491,791

18-acetoxy-1α;,25-dihydroxyvitamin D3

G/A

4.36E−08

ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1

a22758

7

5,223,906

4α-Methylzymosterol-4-carboxylate

G/A

6.50E−13

d12116

 AHR2

7

6,569,111

4α-Methylzymosterol-4-carboxylate

A/G

2.96E−11

Aryl Hydrocarbon Receptor

d12116

 PLPP3

8

26,062,752

PE (2:0/19:0)

G/A

5.11E−09

Phospholipid Phosphatase 3

d13432

 PRKAA2

8

26,124,947

13E,15E,18Z,20Z-pentacosatetraen-11-ynyl acetate

A/G

1.21E−08

Protein Kinase AMP-Activated Catalytic Subunit Alpha 2

a19217

8

26,131,440

PE (2:0/19:0)

G/A

1.17E−08

d13432

 GPAT2

22

5,343,878

LysoPC 20:4

C/T

2.91E−08

Glycerol-3-Phosphate Acyltransferase 2, Mitochondrial

a26448

 PIAS4

28

1,553,948

Monoanhydroescholtzxanthin

C/T

5.06E−11

Protein Inhibitor of Activated STAT 4

c10859

Organic heterocyclic

 XDH

3

4,488,553

Oxypurinol

T/C

8.79E−09

Xanthine Dehydrogenase

a3598

 UGT1A1

7

5,826,779

Biliverdin

C/T

3.70E−19

UDP glucuronosyltransferase 1 family, polypeptide A1

a27158

7

5,826,779

Biliverdin

C/T

6.92E−34

b21472