Fig. 6
From: Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway
MFAEs weakened ferroptosis through antioxidant system in CCl4-induced chronic liver injury mice. A Serum and liver antioxidant levels of indicated mice. B Western blot analysis of total and nuclear Nrf2, Keap-1, HO-1, NQO-1, iNOS, Ferritin, ACSL4, GPX4, SLC7A11, Lc3B, Atg5 (autophagy related 5) and NCOA4 in the livers of indicated mice. Lamin B1 and β-actin served as loading control. C Relative mRNA levels of Nfe2l2, Hmox-1, Nqo-1, Keap-1, Slc7a11, Gpx4 and Acsl4. Results are expressed as mean ± SD. *Indicates a significant difference compared with the control group (*P < 0.05, **P < 0.01). #Indicates a significant difference compared with the 10% CCl4 group (#P < 0.05, ##P < 0.01)