Fig. 2

Transcriptome profile of porcine liver exposed to DON and NaBu supplementation. A Principal component analysis (PCA) plot for the four groups (Vehicle, DON, NaBu, DON+NaBu). B Volcano plots of differential expression profiles among the Vehicle, DON, and DON+NaBu groups. C Venn diagram of the number of genes with significantly differential expression (1.5-fold) changes. D A heatmap of cluster analysis of differential gene samples among the four groups. E GSEA plots depict the enrichment of genes down-regulated in the cholesterol homeostasis pathway in the porcine liver. F A heatmap of mRNA expression changes in cholesterol homeostasis genes, as determined by RNA-seq analysis in porcine liver