Advances on genetic and genomic studies of ALV resistance

Table 2 Antiviral interferon-stimulated genes

Gene	Targeted viruses	Viral life cycle	Mechanism related to antiviral activity	Reference
ACSL1	ALV-J	Replication	Regulating the expression of IFN-I	[130]
CH25H	ALV-J, PRRSV, RABV, reovirus, SARS-CoV-2	Replication	Producing 25-hydroxycholesterol, blocking membrane fusion,	[119, 127, 134,135,136]
IFITM1/2/3	HIV-1; IAVs, lyssaviruses; SARS-CoV	Entry; Restrict viral membrane hemifusion	Unknown, possibly target endocytic pathway	[119, 137,138,139]
Mx	ALV-J, IAVs, NDV, SeV, VSV	Unknown	Unknown	[119, 131, 140]
OASL	ALV-J, NDV, HCV	Unknown	Unknown	[119, 129, 141]
PKR	Capripoxvirus, PRRSV	Replication	Unknown	[119, 142, 143]
ZC3HAV1 (ZAP)	NDV, PRRSV, Retrovirus	Post-entry, translation	Target viral RNA, promote RIG-I signaling	[119, 144,145,146]

ALV-J Subgroup J avian leukosis virus, HCV Hepatitis C virus, IAVs Influenza A viruses; NDV Newcastle disease virus, PRRSV Porcine reproductive and respiratory syndrome virus, RABV Rabies virus, SARS-CoV SARS coronavirus, SeV Sendai virus, VSV Vesicular stomatitis virus

ISSN: 2049-1891