Gestational heat stress alters skeletal muscle gene expression profiles and vascularity in fetal pigs in a sexually dimorphic manner

Table 3 Reactome pathways significantly enriched (false discovery rate (FDR) ≤ 0.05) by the ranked gene list for the comparison of heat stress (HS) vs. control (CON) in female fetal longissimus dorsi (LD) muscles at fetal d 60 age

Reactome pathway	False discovery rate	NES
Interleukin-3, Interleukin-5 and GM-CSF signaling	0.006	−2.09
Calnexin/calreticulin cycle	0.029	−1.96
N-glycan trimming in the ER and calnexin/calreticulin cycle	0.049	−1.89
MAPK family signaling cascades	0.049	−1.45
Fc epsilon receptor (FCERI) signaling	0.049	−1.64
Signaling by insulin receptor	0.049	−1.81
Signaling by receptor tyrosine kinases	0.049	−1.37
FLT3 Signaling	0.049	−1.50
Resolution of Abasic Sites (AP sites)	0.049	1.82

NES Normalised enrichment score. A positive NES, the pathway was mostly enriched by upregulated genes (HS compared to CON). A negative NES, the pathway was mostly enriched by the downregulated genes (HS compared to CON)

ISSN: 2049-1891