A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation

Table 3 Summary of candidate variants described in the study

Variant of interest	dbSNP reference number	Ref/Alt alleles	Alternative allele frequency	R²¹	Effect on protein sequence	Affected gene	SIFT²
NC_030826.1:g. 27,036,324_27,036,326del	NA	GAG/−	0.553 (NZ)	0.877	Inframe deletion	SENP3	NA
NC_030826.1:g. 26,370,181C > T	rs647861802	C/T	0.566 (NZ) 0.038 (NextGen)	0.887	Missense mutation	PSMB6	0.33
NC_030826.1:g. 27,087,979G > T	rs672568929	G/T	0.555 (NZ) 0.028 (NextGen)	0.870	Missense mutation	SHBG	0.01

¹²Linkage disequilibrium values were calculated between the variant of interest and the most significant QTL marker rs268292132 (chr19:26,610,610). SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the amino acid properties. SIFT scores range from 0.0 (deleterious) to 1.0 (tolerated)

ISSN: 2049-1891