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Table 4 Total and differential white blood cells, and serum cytokine and acute-phase proteins in ETEC-infected weaned pigs fed diets supplemented with oligosaccharide-based polymer (Coligo) or antibiotics

From: Supplementation of oligosaccharide-based polymer enhanced growth and disease resistance of weaned pigs by modulating intestinal integrity and systemic immunity

  Diet   P-value
Item1 Control LOW2 HIGH3 CAR4 SEM Diet Linear5
d 0 before infection
 WBC, 103/μL 15.28 16.91 15.70 16.85 1.00 0.58 0.77
 Neu, 103/μL 7.93 9.03 8.43 7.56 0.67 0.46 0.60
 Lym, 103/μL 6.39b 6.72b 6.08b 8.26a 0.48 < 0.05 0.65
 Mono, 103/μL 0.66 0.83 0.79 0.75 0.11 0.73 0.41
 Eos, 103/μL 0.24 0.27 0.35 0.20 0.10 0.64 0.33
 Baso, 103/μL 0.057 0.072 0.051 0.075 0.018 0.074 0.81
Serum
 TNF-α, pg/mL 63.56 59.67 61.51 72.80 1.62 0.98 0.99
 C-reactive protein, μg/mL 7.37 6.86 8.57 8.08 1.39 0.86 0.46
 Haptoglobin, g/mL 0.984 0.730 1.211 1.072 0.135 0.065 0.031
d 2 PI
 WBC, 103/μL 21.16a 18.04ab 17.78b 18.53ab 1.01 < 0.05 < 0.05
 Neu, 103/μL 12.25a 9.83b 9.79b 8.34b 0.96 < 0.05 < 0.05
 Lym, 103/μL 7.27ab 6.97b 6.79b 8.54a 0.41 < 0.05 0.41
 Mono, 103/μL 1.16 1.05 0.85 1.33 0.16 0.29 0.21
 Eos, 103/μL 0.40 0.25 0.19 0.23 0.10 0.09 < 0.05
 Baso, 103/μL 0.106a 0.036b 0.039b 0.029b 0.017 < 0.05 < 0.05
Serum
 TNF-α, pg/mL 107.92 67.06 66.28 66.28 32.89 0.63 0.28
 C-reactive protein, μg/mL 20.42a 22.74a 22.88a 12.38b 2.693 0.018 0.65
 Haptoglobin, g/mL 1.306ab 1.142b 1.561a 1.066b 0.127 < 0.05 0.11
d 5 PI
 WBC, 103/μL 21.00 18.56 18.67 18.19 1.09 0.14 0.15
 Neu, 103/μL 10.93a 9.17b 9.54ab 7.89b 0.54 < 0.05 < 0.05
 Lym, 103/μL 9.03 8.22 8.02 8.35 0.65 0.69 0.25
 Mono, 103/μL 0.86 0.86 0.79 1.21 0.15 0.29 0.74
 Eos, 103/μL 0.13b 0.26ab 0.25ab 0.55a 0.14 < 0.05 0.41
 Baso, 103/μL 0.059 0.043 0.078 0.057 0.016 0.49 0.41
Serum
 TNF-α, pg/mL 90.64 68.36 54.39 32.99 32.88 0.25 0.16
 C-reactive protein, μg/mL 21.61a 17.46ab 19.84ab 15.96b 1.72 0.082 0.93
 Haptoglobin, g/mL 1.655a 1.084b 1.348ab 1.154b 0.128 0.081 0.93
d 11 PI
 WBC, 103/μL 16.15 17.40 17.32 14.92 1.58 0.64 0.57
 Neu, 103/μL 8.68 10.71 9.67 8.12 1.22 0.16 0.40
 Lym, 103/μL 6.33 6.69 7.21 6.39 0.63 0.76 0.35
 Mono, 103/μL 0.66 1.12 0.99 1.39 0.19 0.10 0.21
 Eos, 103/μL 0.18 0.31 0.24 0.21 0.13 0.74 0.57
 Baso, 103/μL 0.058 0.083 0.048 0.042 0.025 0.51 0.70
Serum
 TNF-α, pg/mL 82.58 84.62 72.71 59.39 28.03 0.96 0.79
 C-reactive protein, μg/mL 21.95a 17.71ab 18.29ab 12.61b 2.89 0.091 0.65
 Haptoglobin, g/mL 0.819 0.599 0.538 0.412 0.178 0.24 0.31
  1. a,bWithin a row, means without a common superscript differ (P < 0.05)
  2. 1WBC white blood cell, Neu neutrophil, Lym lymphocyte, Mono monocyte, Eos eosinophil, Baso basophil, PI post-inoculation. Each least squares mean represents 12 observations, except d 11 PI that has 6 observations
  3. 2LOW Low dose blood group A6 type 1-based polymer (Coligo)
  4. 3HIGH High dose blood group A6 type 1-based polymer (Coligo)
  5. 4CAR carbadox
  6. 5Linear effects of adding Coligo to the control diet