Table 1 Change in miRNA expression in various subjects caused by the four mycotoxins
From: MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro
Mycotoxins | Dose | Test object | Up | Down | Reference |
|---|---|---|---|---|---|
OTA | 200 μg/kg | Piglet | miR-497 miR-133a-3p miR-423-3p miR-34a miR-542-3p | miR-421-3p miR-490 miR-9840-3p | [16] |
1000 nmol/L | NRK-52E NRK-49F | miR-21 miR-200a | \ | [17] | |
25 μmol/L | LLC-PK-1 | miR-200c miR-29c miR-29b miR-132 | miR-17 miR-192 miR-200b | [18] | |
210 μg/kg | Rats | miR-3596b miR-653 miR-3065-3p | miR-129 miR-130b miR-141 | [19] | |
ZEA | 50 μmol/L | TM3 | miR-19a-3p miR-96-5p miR-221-5p miR-3057-5p | miR-146-3p miR-3095-5p miR-185-3p miR-467e-3p | [20] |
58 mg/kg | Piglets | miR-1 miR-424-5p miR-452-3p | \ | [21] | |
40 μg/kg | Sus scrofa | miR-15a miR-21 miR-192 | \ | [22] | |
AFB1 | 200 μg/kg | F344 Rats | miR-122-5p miR-34a-5p miR-181c-3p | \ | [23] |
1.5 mg/kg | F344 male Rats | miR-146a miR-24 miR-199a-3p miR-23a | miR-122 miR-192 miR-101b miR-30a | [24] | |
200 μg/kg | Rats | miR-182 miR-10b-5p miR-224-5p miR-122-5p | miR-802-5p | [25] | |
200 μg/kg | Rats | miR-34a-5p miR-200b-3p miR-429 | miR-130a-3p | [26] | |
DON | 1.6 μg/mL | JPEC-J2 | miR-181a miR-30c miR-365-5p miR-769-3p | \ | [27] |