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Table 3 The effect of dietary LNT supplementation and/or RV challenge on mRNA expressions of host defense peptides and immune-related genes in the jejunal mucosa of weaned pigs

From: Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity

  − RV + RV P-value
CON LNT CON LNT RV LNT LNT × RV
pBD1 1.00 ± 0.09b 1.22 ± 0.03a 0.45 ± 0.04d 0.79 ± 0.05c < 0.05 < 0.05 0.30
pBD2 1.00 ± 0.06a 1.13 ± 0.07a 0.51 ± 0.05c 0.79 ± 0.03b <  0.05 <  0.05 0.20
pBD3 1.00 ± 0.09b 1.27 ± 0.06a 0.58 ± 0.02c 0.94 ± 0.05b < 0.05 < 0.05 0.52
pBD3 1.00 ± 0.09b 1.27 ± 0.06a 0.58 ± 0.02c 0.94 ± 0.05b <  0.05 <  0.05 0.52
TLR3 1.00 ± 0.12b 1.75 ± 0.10a 1.69 ± 0.25a 1.89 ± 0.21a < 0.05 < 0.05 0.18
RIG-1 1.00 ± 0.09c 1.14 ± 0.09bc 1.34 ± 0.09ab 1.94 ± 0.23a <  0.05 <  0.05 0.12
MDA5 1.00 ± 0.09b 1.49 ± 0.17ab 1.61 ± 0.16a 1.97 ± 0.25a < 0.05 < 0.05 0.72
MAVS 1.00 ± 0.05b 2.21 ± 0.16a 2.07 ± 0.19a 2.32 ± 0.21a <  0.05 <  0.05 <  0.05
IFN-β 1.00 ± 0.06c 1.42 ± 0.15b 1.57 ± 0.08b 2.13 ± 0.18a < 0.05 < 0.05 0.59
ISG-15 1.00 ± 0.10c 1.34 ± 0.15bc 1.85 ± 0.25 ab 2.41 ± 0.26a <  0.05 <  0.05 0.58
  1. − RV infusing the essential medium, + RV infusing the porcine rotavirus, CON basal diet, LNT LNT-supplemented diet, pBD1 porcine beta-defensin 1, pBD2 porcine beta-defensin 2, pBD3 porcine beta-defensin 3, TLR3 Toll-like receptor 3, RIG-I retinoic acid inducible protein 1, MDA5 melanoma differentiation-associated protein 5, MAVS mitochondrial antiviral signaling protein, IFN-β interferon-beta, ISG-15 interferon stimulated gene 15
  2. a, b, c, d Mean values within a row with different superscript letters were significantly different (P < 0.05)