Fig. 2
The ECS enhances transcriptional machinery of PPARγ and lipid accumulation, promoting adipogenesis and lipogenesis in maturing progenitor cells. Red arrows: inhibitory effect downstream of eCB stimulation. Green arrows: stimulatory effect downstream of eCB stimulation. Abbreviations: Adenylyl cyclase (AC), adiponectin (ApN), Cannabinoid receptor 1 (CB1), Cyclic adenosine monophosphate response element-binding protein (CREB), Endocannabinoid (eCB), Extracellular signal-regulated kinase (ERK), Fatty acid binding protein 4 (FABP4), Fatty acid translocase (CD36), Fatty acid transport protein (FATP), Fibroblast growth factor 1, 2, 10 (FGF1, 2, 10), Free fatty acid (FFA), Gi protein subunit o (Gi/o), Glucose transporter type 4 (GLUT-4), insulin (I), Insulin receptor (IR), Insulin receptor substrate (IRS), Lipoprotein lipase (LPL), Peroxisome proliferator-activated receptor gamma (PPARγ), Retinoid X receptor (RXR), Tumor necrosis factor alpha (TNFα), Vascular endothelial growth factor D (VEGF-D)