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Table 4 The most enriched GO biological process terms assigned to the 105 up-regulated and 61 down-regulated transcripts in the liver of pigs of group IM10 compared with group CONa

From: Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L. in growing pigs by transcriptomics, metabolomics and lipidomics

GO biological process term

Number of genes

P-value

Fold enrichment

Up-regulated transcripts

 Regulation of sequence-specific DNA binding transcription factor activity

7

0.001

5.8

 Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

4

0.004

12.6

 Transcription, DNA-templated

18

0.005

2.0

 Tube development

8

0.005

3.7

 Rhythmic process

5

0.007

6.4

 Leukocyte activation involved in immune response

5

0.010

5.8

 Cell activation involved in immune response

5

0.010

5.8

 Cell development

14

0.011

2.1

 Negative regulation of sequence-specific DNA binding transcription factor activity

4

0.011

8.5

 BMP signaling pathway

4

0.014

7.8

 Cellular process involved in reproduction in multicellular organism

5

0.016

5.1

 Response to BMP

4

0.016

7.4

 Cellular response to BMP stimulus

4

0.016

7.4

 Termination of RNA polymerase I transcription

2

0.017

115.2

 Regulation of gene expression

20

0.021

1.7

 Regulation of macromolecule biosynthetic process

19

0.021

1.7

 Transmembrane receptor protein serine/threonine kinase signaling pathway

5

0.021

4.7

 Regulation of cell differentiation

11

0.022

2.2

 Nucleic acid-templated transcription

18

0.022

1.7

 Positive regulation of macromolecule metabolic process

16

0.023

1.8

 Positive regulation of cellular metabolic process

16

0.023

1.8

 RNA biosynthetic process

18

0.024

1.7

 Transcription from RNA polymerase II promoter

11

0.027

2.2

 Fc receptor signaling pathway

2

0.028

69.1

 Cellular response to chemical stimulus

14

0.032

1.8

 Regulation of cellular macromolecule biosynthetic process

18

0.033

1.6

 Lipid metabolic process

9

0.035

2.3

 Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

4

0.037

5.4

 Nucleobase-containing compound biosynthetic process

19

0.037

1.6

 Positive regulation of metabolic process

16

0.039

1.7

 Regulation of transcription from RNA polymerase II promoter

11

0.042

2.0

 Regulation of nitrogen compound metabolic process

19

0.043

1.6

 Heterocycle biosynthetic process

19

0.044

1.6

 Positive regulation of macromolecule biosynthetic process

10

0.044

2.1

 Negative regulation of transport

5

0.045

3.7

 Positive regulation of kinase activity

5

0.045

3.7

 Aromatic compound biosynthetic process

19

0.045

1.6

 Regulation of osteoblast differentiation

3

0.046

8.6

 Negative regulation of cell differentiation

6

0.048

3.0

 Endothelial cell differentiation

3

0.049

8.4

 Positive regulation of protein serine/threonine kinase activity

4

0.049

4.8

Down-regulated transcripts

 Urea metabolic process

2

0.021

91.0

 Urea cycle

2

0.021

91.0

 Nitrogen cycle metabolic process

2

0.026

74.5

 Cellular response to chemical stimulus

8

0.028

2.5

 Arginine metabolic process

2

0.032

58.5

 Negative regulation of establishment of protein localization

3

0.033

10.2

 Leukocyte cell-cell adhesion

4

0.034

5.4

 Protein folding

3

0.039

9.2

  1. aGO terms are sorted by their fold enrichment score in descending order. Only GO terms with EASE scores (enrichment P-value) < 0.05 are shown
  2. Abbreviations: CON control group; GO gene ontology; IM10 insect meal 10% group
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Journal of Animal Science and Biotechnology

ISSN: 2049-1891