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Table 4 The most enriched GO biological process terms assigned to the 105 up-regulated and 61 down-regulated transcripts in the liver of pigs of group IM10 compared with group CONa

From: Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L. in growing pigs by transcriptomics, metabolomics and lipidomics

GO biological process term Number of genes P-value Fold enrichment
Up-regulated transcripts
 Regulation of sequence-specific DNA binding transcription factor activity 7 0.001 5.8
 Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 4 0.004 12.6
 Transcription, DNA-templated 18 0.005 2.0
 Tube development 8 0.005 3.7
 Rhythmic process 5 0.007 6.4
 Leukocyte activation involved in immune response 5 0.010 5.8
 Cell activation involved in immune response 5 0.010 5.8
 Cell development 14 0.011 2.1
 Negative regulation of sequence-specific DNA binding transcription factor activity 4 0.011 8.5
 BMP signaling pathway 4 0.014 7.8
 Cellular process involved in reproduction in multicellular organism 5 0.016 5.1
 Response to BMP 4 0.016 7.4
 Cellular response to BMP stimulus 4 0.016 7.4
 Termination of RNA polymerase I transcription 2 0.017 115.2
 Regulation of gene expression 20 0.021 1.7
 Regulation of macromolecule biosynthetic process 19 0.021 1.7
 Transmembrane receptor protein serine/threonine kinase signaling pathway 5 0.021 4.7
 Regulation of cell differentiation 11 0.022 2.2
 Nucleic acid-templated transcription 18 0.022 1.7
 Positive regulation of macromolecule metabolic process 16 0.023 1.8
 Positive regulation of cellular metabolic process 16 0.023 1.8
 RNA biosynthetic process 18 0.024 1.7
 Transcription from RNA polymerase II promoter 11 0.027 2.2
 Fc receptor signaling pathway 2 0.028 69.1
 Cellular response to chemical stimulus 14 0.032 1.8
 Regulation of cellular macromolecule biosynthetic process 18 0.033 1.6
 Lipid metabolic process 9 0.035 2.3
 Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 4 0.037 5.4
 Nucleobase-containing compound biosynthetic process 19 0.037 1.6
 Positive regulation of metabolic process 16 0.039 1.7
 Regulation of transcription from RNA polymerase II promoter 11 0.042 2.0
 Regulation of nitrogen compound metabolic process 19 0.043 1.6
 Heterocycle biosynthetic process 19 0.044 1.6
 Positive regulation of macromolecule biosynthetic process 10 0.044 2.1
 Negative regulation of transport 5 0.045 3.7
 Positive regulation of kinase activity 5 0.045 3.7
 Aromatic compound biosynthetic process 19 0.045 1.6
 Regulation of osteoblast differentiation 3 0.046 8.6
 Negative regulation of cell differentiation 6 0.048 3.0
 Endothelial cell differentiation 3 0.049 8.4
 Positive regulation of protein serine/threonine kinase activity 4 0.049 4.8
Down-regulated transcripts
 Urea metabolic process 2 0.021 91.0
 Urea cycle 2 0.021 91.0
 Nitrogen cycle metabolic process 2 0.026 74.5
 Cellular response to chemical stimulus 8 0.028 2.5
 Arginine metabolic process 2 0.032 58.5
 Negative regulation of establishment of protein localization 3 0.033 10.2
 Leukocyte cell-cell adhesion 4 0.034 5.4
 Protein folding 3 0.039 9.2
  1. aGO terms are sorted by their fold enrichment score in descending order. Only GO terms with EASE scores (enrichment P-value) < 0.05 are shown
  2. Abbreviations: CON control group; GO gene ontology; IM10 insect meal 10% group