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Table 6 Relative mRNA abundances of genes of the unfolded protein response (UPR) and genes of the Nrf2 pathway in the liver of cows fed the control diet (Con) or the diet supplemented with green tea extract (GTE) in weeks 1, 4 and 7 of lactation1

From: Effects of supplementation of green tea extract on the milk performance of peripartal dairy cows and the expression of stress response genes in the liver

 Week 1 Week 4 Week 7 P-value
ConGTESEMConGTESEMConGTESEMGTEWeekGTE × weekParity
Genes of Nrf2 pathway2
CAT1.001.020.181.110.920.181.411.230.180.150.0030.490.036
GPX11.001.100.190.79a1.29b0.191.021.210.190.250.670.120.053
MT1A1.000.710.320.190.350.160.100.150.320.85<  0.0010.370.81
NQO11.000.900.170.970.840.171.090.970.170.190.380.980.34
SOD11.000.890.100.950.850.101.000.920.100.080.480.960.16
UGT1A11.000.980.170.880.670.171.040.920.170.170.070.640.34
Genes of UPR2
ATF41.000.870.080.960.980.081.040.990.080.360.410.490.98
BAK11.001.320.320.761.270.320.901.060.320.190.610.710.11
BAX1.000.940.191.491.430.191.121.250.190.710.0010.710.12
CASP31.00a0.77b0.100.900.790.100.810.710.100.060.060.420.46
CASP81.000.760.141.071.130.140.971.010.140.820.0170.100.28
DDIT31.000.730.140.971.150.140.960.910.140.960.0510.0280.08
DNAJC31.00a0.57b0.160.861.010.160.810.810.160.340.210.0060.79
EDEM11.000.620.201.091.360.161.201.500.160.500.0010.0120.48
HERPUD11.000.890.160.690.770.160.760.760.160.790.100.660.48
HSPA51.00a0.57b0.200.620.670.200.600.590.200.200.320.110.47
PDIA41.000.640.190.750.930.190.930.820.190.310.910.100.49
XBP1s1.000.610.210.330.680.210.420.490.210.870.0460.0550.19
  1. 1Values are least square means, n = 15 for each group
  2. 2Relative mRNA abundances of Con in week 1 are set as a reference (=1.00)
  3. a,b Means within one week with different superscripts differ significantly (P < 0.05)
  4. Nrf2 Nuclear factor-erythroid 2-related factor 2, SEM standard error of means, UPR unfolded protein response