Table 2 Individual measurements of IL-1β concentration (pg/mL) in blood plasma and cerebrospinal fluid (CSF) in sham-implanted and melatonin implanted ewes before and 3 h after lipopolysaccharide (LPS, 400 ng/kg) administration
Sham-implanted | Melatonin-implanted | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Plasma, pg/mL | CSF, pg/mL | Plasma, pg/mL | CSF, pg/mL | ||||||
Ewe # | Before | After LPS | Before | After LPS | Ewe # | Before | After LPS | Before | After LPS |
1 | 0.0 | 65.3 | 27.8 | 48.0 | 1 | 143.3 | 211.0 | 26.4 | 410.8 |
2 | 0.0 | 105.9 | 13.5 | 35.5 | 2 | 128. | 134.7 | 67.4 | 146.5 |
3 | 53.0 | 58.5 | 21.0 | 50.4 | 3 | 0.0 | 210.7 | 19,2 | 39.6 |
4 | 76.1 | 113.0 | 20.3 | 365.6 | 4 | 0.0 | 298.4 | 0.0 | 198.5 |
5 | 197.2 | 399.0 | 22.8 | 66.7 | 5 | 0.0 | 80.3 | 0.0 | 12.3 |
6 | 49.4 | 214.2 | 51.7 | 213.7 | 6 | 192.7 | 378.7 | 24.2 | 54.0 |
7 | 0.0 | 71.0 | 11,8 | 115.4 | |||||
Mean (±SEM) | 62.0 (±29.7) | 159.3a (±53.1) | 26.2 (±5.4) | 129.8a (±54.2) | 66.4 (±32.1) | 197.8a (±42.8) | 21.3 (±8.7) | 139.6a (±51.5) | |