Fig. 1

Temporal concentrations [−7 to 14 d relative to diet initiation; before TZD administration and 15 to 28 d relative to diet initiation (during TZD administration)] of blood biomarkers in cows fed either a controlled-energy diet (CON, 1.30 Mcal/kg diet dry matter; n = 7) or a moderate-energy diet (OVE, 1.60 Mcal/kg diet dry matter; n = 7) before (left panels) and during (right panels) 2,4-thiazolidinedione (TZD) administration. *Significant (P < 0.05) difference due to diet or Diet × Time. ^a,bSignificant (P < 0.05) overall difference due to time