Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep

Table 1 Non-synonymous mutations in mitochondrial coding genes and corresponding effects on litter size

Gene	Nucleotide^a	Codon mutation	Amid acid substitution	Significance^b
ND1	T3543A	UCA → ACA	S → T	ns
ND2	T4208C	AUA → ACA	M → T	ns
COII	C7500A	CCC → CAC	P → H	ns
ATP6	A8039G	AAC → AGC	N → S	ns
ATP6	G8264C	GGA → GCA	G → A	ns
COIII	A9375G	AUA → GUA	M → V	ns
ND4L	C9974T	CCU → UCU	P → S	ns
ND4L	G10118A	GGU → AGU	G → S	ns
ND4	G10937A	GAC → AAC	D → N	ns
ND4	G11045A	GUU → AUU	V → I	ns
ND5	G12571C	GGC → GCC	G → A	ns
ND5	G13041A	GCA → ACA	A → T	ns
ND6	C13576T	CUC → UUC	L → F	ns
	T13588C	UAC → CAC	Y → H	ns
	C13777T	CAU → UAU	H → Y	ns
	C13789T	CAU → UAU	H → Y	ns
	T13837C	UCA → CCA	S → P	ns
	T13855C	UUC → CUC	F → L	ns
	A13876G	AUA → GUA	M → V	ns
12SrRNA	T281C	-	-	ns
	C291T	-	-	ns
	A538G	-	-	ns
16SrRNA	A1099T	-	-	ns
	T1112C	-	-	ns
	T2199A	-	-	ns
	C2443T	-	-	ns
	T2634C	-	-	ns
tRNA-Tyr	G5295A	-	-	ns
tRNA-Lys	T7719G	-	-	*
tRNA-His	C11606T	-	-	ns
tRNA-Ser	G11668A	-	-	ns

^aMutation positions were defined according to the ovine mitochondrial sequence (GenBank Accession nos.: AF010406)
^bWhen a set of statistical inferences were simultaneously considered, multiple comparisons were conducted by the FDR using the R project. “ns” represents “not significant”, and “*” represents “significant” at the significant level of 0.05

ISSN: 2049-1891