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Table 4 Effect of h[Gly2]GLP-21-34 pretreatment on the intestinal morphology of weaned pigs exposed to LPSa

From: The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Item Treatmentb Pooled SEM Contrastc
  Control LPS LPS + Low GLP-2 LPS + High GLP-2 1 2 3
Duodenum
Villus height, μm 438 335 420 438 8 <0.001 <0.001 <0.001
Crypt depth, μm 242 257 264 237 3 0.094 0.415 0.027
VCR 1.81 1.31 1.60 1.85 0.04 <0.001 <0.001 <0.001
Jejunum
Villus height, μm 341 284 322 353 7 0.001 0.019 <0.001
Crypt depth, μm 210 207 227 212 3 0.708 0.017 0.477
VCR 1.63 1.38 1.43 1.67 0.03 0.005 0.607 0.002
Ileum
Villus height, μm 306 239 259 324 6 <0.001 0.041 <0.001
Crypt depth, μm 199.5 205.3 209.9 209.0 1.8 0.259 0.377 0.863
VCR 1.54 1.16 1.24 1.56 0.03 <0.001 0.237 <0.001
  1. aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide; VCR = Villus height/Crypt depth ratio
  2. bControl: piglets injected with sterile saline on d 14 postweaning; LPS: pigs challenged by LPS on d 14 postweaning; LPS + Low and LPS + High GLP-2: piglets pretreated with GLP-2 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning were challenged by LPS on d 14 postweaning. The data were obtained 24 h after injection with LPS and 15 d post-weaning
  3. cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates