Table 2 Suggested candidate genes/pathways against porcine Gram-negative bacilli ^§

S. Typhimurium

*

HP, NCF2, PGD[3]

intestine (jejunum, ileum and colon)

TLR-2, NOD-1, NOD-2, PBD-2, NF-κB1, caspase-1 Regional differences in gene expression profiles and inflammatory response to S. typhimurium infection along the porcine intestinal gut exist [64]

macrophage

Enhanced uptake of S. typhimurium in macrophages is associated with ERK1/2 activation [63]

intestinal epithelial cell

PBD-1, PBD-2[61, 67, 68]

*

CCT7[69]

in vivo gut loop model

NOD-2, TLR-2, TLR-4, TLR5, CCR9, CCRL1[65]

mesenteric lymph node

T helper 1, innate/inflammatory, and antigen-processing pathways are induced; apoptosis and antigen presentation/dendritic cell function pathways are down-regulated; NF-kappaB suppression in antigen-presenting cells may be the mechanism for S. Typhimurium evasion [62]

mesenteric lymph node

CD47, CXCL10, SCARB2, INDO, IRF1, SOCS1, STAT1, SLC11A1[47]

S. Choleraesuis

*

14 different chromosomal regions in the porcine genome are found to be significantly associated with susceptibility [24]

mesenteric lymph node

Th1, innate immune/inflammation response, apoptosis pathway, and strong NF-kappaB-dependent response are induced [35]

mesenteric lymph node

ARPC2, CCT7, HSPH1, LCP1, PTMA, SDCBP, VCP, INDO, SOCS1, STAT1, SLC11A1[48]

lung

TGM1, TGM3, GBP1, GBP2, C1S, C1R, MHC2TA, PSMB8, TAP1, TAP2

Apoptotic pathways, Th1 immune response, and interferon gamma (IFNG) signal are observed [2, 66]

E. coli

*

HEG1, ITGB5[70]; MUC4[71, 72]; FUT1[73, 74]; B3GNT5[75, 76]; MUC20[77]; MUC13[18]; TFRC[75, 78]; B3GALT3, B4GALT4[75]

duodenum

Genes related to the Glycan Biosynthesis and Metabolism are observed [79]

Jejunal mucosa

THO complex 4 [80]

A. pleuropneumoniae

lung

MMP-9, MMP-12[81]

liver

liver plays an important role in initiating and orchestrating the innate immune response to A. pleuropneumoniae infection [82]

*

TF[83]

peripheral blood leukocytes

OAS1, CD97, S100A8, TGM3[84]

lung, liver, tracheobronchial lymph node

357, 713, and 130 differentially expressed genes are observed in lung, liver, and tracheobronchial lymph node, respectively (For more details see [85])

H. parasuis

porcine alveolar macrophage

S100A4, S100A6, coronin1a, etc. Cell adhesion molecules, cytokine-cytokine receptor interaction, complement and coagulation cascades, toll-like receptor signaling pathway, and MAPK signaling pathway are significantly effected [86]

*

FUT1[87]

lung

Candidate genes and pathways for disease resistance or susceptibility phenotypes are identified (For more details see [88])

*

CAV1[89]

spleen

S100A8, S100A9, RETN, etc. [4, 49]

L. intracellularis

intestinal tissue

IGFBP-3[90]

K. pneumoniae

N/A

N/A

Y. pseudotuberculosis

N/A

N/A

Y. enterocolitica

N/A

N/A

C. coli

N/A

N/A