Figure 2

Histotroph includes molecules secreted or transported into the uterine lumen to stimulate growth and development of the conceptus during the peri-implantation period and for the duration of pregnancy in species with epitheliochorial and syndesmochorial placentae. The uterine luminal (LE) and superficial glandular (sGE) epithelia (blue color) in closest proximity to trophectoderm express novel genes in response to progesterone and interferon tau that support conceptus development in ewes. The uterine glandular (GE) and stromal cells express classical interferon stimulated genes during the peri-implantation period of pregnancy.