Fig. 4
Tissue pattern and pleiotropic of eQTLs, and TWAS. a The number of eGenes overlap between tissues. b Pairwise sharing patterns of cis-eQTL (π1 value) across tissues. c The increased number of eGenes discovered by multi-tissue cis-eQTL analyses. d Locuszoom plots of the genetic signals regulating genes at cluster 10:64,961,096–65,908,904. The nominal P-values of all local variant-gene associations regarding C10H15orf48, bta-mir-147, and FERMT2 were shown. The colors of variants are based on their LD with the most significant eVariant. e The proportion of eQTLs (y-axis) with chromatin states using fine mapping eVariants, top significant eVariants and total eVariants. f Distribution of cis-H2. The solid line corresponds to all tested genes, while the dashed lines are cis-heritable genes. g Manhattan plot of TWAS between muscle gene expression and daily gain weight