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Fig. 1 | Journal of Animal Science and Biotechnology

Fig. 1

From: The eQTL colocalization and transcriptome-wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle

Fig. 1

Study design and transcriptome associated with traits. a We investigated the molecular characteristics by profiling genotype, and mRNA from liver, muscle and adipose tissue of 120 Simmental cattle with important agronomic traits. We identified the promising candidate genes and causal variants using a multi-omics association strategy. b The Manhattan plot of 21 agronomic traits. Only significant variants and their nearby SNPs within up/downstream 100 kb are shown in the plot. The closest gene and associated traits of each sentinel SNP were labeled on the top. c Sample clustering using t-SNE based on gene expression levels. d Pearson correlation (heatmap) and hierarchical clustering (tree) of transcriptome profiles across 356 samples (rows/columns) show tissue-specific clustering (colors). e Correlation of gene co-expression modules with agronomic traits in muscle. Modules were denoted by different colors. Correlation of module eigengene with each agronomic trait displayed in the corresponding box (top: coefficient, bottom: P-value). The color of each box represents a positive correlation (red) or a negative correlation (blue)

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