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Table 2 Application of resveratrol in poultry production

From: Biological function of resveratrol and its application in animal production: a review

Animal

Dosage

Stress model/

study design

Main beneficial effects

Reference

Quails

5-week-old

200, 400 mg

12-week feeding

Exhibited a linear decrease in serum and egg yolk MDA and a linear increase in serum vitamin E

[15]

Laying hens

60-week-old

0.5, 1.0, 2.0, and 4.0 g/kg

8-week feeding

Reduced FCR; improved Haugh unit and albumen height of eggs and decreased contents cholesterol in the yolk

[138]

Laying hens

210-day-old

200, 400, and 800 mg/kg

1-month feeding

Increased egg production rate and ADFI and decreased feed-to-egg ratio; reduced egg cholesterol content; extended egg shelf life and improved egg sensory scores and yolk index

[139]

Ducks

1-day-old

150, 300, and 450 mg/kg

21-d feeding

Improved meat quality in leg muscle, including meat color, pH, drip loss and shear force

[140]

Broilers

21-day-old

400 mg/kg

21-d feeding

Decreased L*, pH decline, drip loss, and lactate content in pectoralis major muscle; increased antioxidant state and PGC-1α and nuclear NRF1 mRNA expression and citrate synthase activity

[141]

Broilers

21-day-old

400 mg/kg

Transport stress,

21-d feeding

Improved feed conversion ratio and tended to improve final BW; increased glycogen content, LDH activity, and drip loss in the muscle of transported broilers

[142]

Broilers

1-day-old

300, 600 mg/kg

E. coli,

42-d feeding

Increased ADG and decreased FCR of broilers challenged with E. coli; increased villus length to crypt depth and decreased E. coli number in challenged chickens

[143]

Ducks

1-day-old

500 mg/kg

Aflatoxin B1,

42-d feeding

Increase II-phase enzyme activity, activate NRF2 signal pathway, and protect oxidative stress and inflammatory reaction in the liver induced by AFB1

[144]

Ducks

1-day-old

500 mg/kg

Aflatoxin B1,

70-d feeding

Alleviated ileum injury induced by AFB1, decreased the production of AFB1-DNA adducts and reduced DNA damage and oxidative stress via NRF2/KEAP1 and NF-κB/NLRP3 signaling pathways

[145]

Chicken

1-day-old

200, 400 and 800 mg/kg

Conventional vaccinations,

40-d feeding

Increased ADG and antibody titers against Newcastle disease virus and avian influenza viruses H5 and H9

[146]

Ducks

1-day-old

400 mg/kg

LPS treatment,

28-d feeding

Improved final BW and ADG before LPS treatment; alleviated LPS-induced inflammatory response in liver and intestine and increased tight junction protein expression

[147, 148]

Ducks

1-day-old

300, 400 and 500 mg/kg

70-d feeding

Increased pH and reduced MDA, carbonyl contents, and shear force, thereby improving water mobility and distribution, drip loss and cooking loss of duck meat; inhibited the formation of carbonyl and dityrosine and reduced the loss of sulfhydryl in frozen-thawed duck breast meat

[149, 150]

Quails

55-day-old

200, 400 mg/kg

Heat stress,

12-week feeding

Increased ADFI and egg production; increased hepatic SOD, CAT, and GPX activities as well as NRF2 expression, decreased hepatic MDA concentrations and Hsp70, Hsp90, and NF-κB expressions

[151]

Black-boned chickens

42-day-old

200, 400 and 600 mg/kg

Heat stress,

15-d feeding

Increased feed intake and BW gain; improved villus morphology, numbers of goblet cells and lymphocytes and regulated heat shock protein expression in the thymus and intestine

[19, 152]

Broilers

21-day-old

400 mg/kg

Heat stress,

21-d feeding

Increased final BW of heat-stressed broilers; decreased crypt depth and E. coli populations, and increased villus height, goblet cells numbers, populations of Lactobacillus and Bifidobacterium; Increased a*, pH24h, and decreased L*, drip loss and muscle MDA content of heat-stress broilers

[20, 153]

Broilers

28-day-old

200, 350,

and 500 mg/kg

Heat stress,

14-d feeding

Improved ADG and decreased rectal temperature of heat-stressed broilers; lowered contents of corticosterone and adrenocorticotropic hormone

[154]

Broilers

28-day-old

500 mg/kg

Heat stress,

14-d feeding

Increased ADFI and ADG under heat stress; decreased crypt depth, increased villus height; increased gene expression related to gut barrier and decreased gene expression related to inflammation; improved immune organ index and inhibited the NF-κB, MAPK, and PI3K/AKT signaling pathway in spleen

[66, 155]

Broilers

21-day-old

400 mg/kg

Heat stress,

21-d feeding

Increased BW and ADG under heat stress; increased relative jejunum weight, relative length of ileum, jejunal villus height, activities of GPX and GST, and mRNA levels of NRF2 and SOD1 under heat stress

[156]

Ducks

60-day-old

400 mg/kg

Heat stress,

15-d feeding

Increased the ratio of villus height to crypt depth and the number of goblet cells and reduced the histopathological damage of jejunum; activated SIRT1-NRF1/NRF2 signaling pathways, improved ATP level of jejunum

[157]

Broilers

28-day-old

500 mg/kg

Heat stress,

14-d feeding

Decreased FCR under heat stress; decreased levels of corticosterone and adrenocorticotropic hormone caused and reduced heat stress-induced apoptotic cells and apoptosis genes

[158]

  1. MDA malondialdehyde, PGC-1α peroxisome proliferators-activated receptor gamma coactivator-1 alpha, ADFI average daily feed intake, ADG average daily gain, FCR feed conversion ratio, BW body weight, NRF1 nuclear respiratory factor 1, CAT catalase, GPX glutathion peroxidase, NRF2 nuclear factor erythroid 2-related factor 2, NF-κB nuclear factor κB, KEAP1 kelch-like ECH-associated protein 1, SOD superoxide dismutase, MAPK mitogen-activated protein kinases, LPS lipopolysaccharides, GST glutathione S-transferase, SIRT1 sirtuin 1, LDH lactate dehydrogenase, AFB1 aflatoxin B1, Hsp heat-shock protein 70, PI3K phosphoinositide-3 kinases, AKT protein kinase B, NLRP3 NOD-like receptor protein 3, a* redness, L* lightness