From: Biological function of resveratrol and its application in animal production: a review
Animal | Dosage | Stress model/ study design | Main beneficial effects | Reference |
---|---|---|---|---|
Quails 5-week-old | 200, 400Â mg | 12-week feeding | Exhibited a linear decrease in serum and egg yolk MDA and a linear increase in serum vitamin E | [15] |
Laying hens 60-week-old | 0.5, 1.0, 2.0, and 4.0Â g/kg | 8-week feeding | Reduced FCR; improved Haugh unit and albumen height of eggs and decreased contents cholesterol in the yolk | [138] |
Laying hens 210-day-old | 200, 400, and 800Â mg/kg | 1-month feeding | Increased egg production rate and ADFI and decreased feed-to-egg ratio; reduced egg cholesterol content; extended egg shelf life and improved egg sensory scores and yolk index | [139] |
Ducks 1-day-old | 150, 300, and 450Â mg/kg | 21-d feeding | Improved meat quality in leg muscle, including meat color, pH, drip loss and shear force | [140] |
Broilers 21-day-old | 400 mg/kg | 21-d feeding | Decreased L*, pH decline, drip loss, and lactate content in pectoralis major muscle; increased antioxidant state and PGC-1α and nuclear NRF1 mRNA expression and citrate synthase activity | [141] |
Broilers 21-day-old | 400Â mg/kg | Transport stress, 21-d feeding | Improved feed conversion ratio and tended to improve final BW; increased glycogen content, LDH activity, and drip loss in the muscle of transported broilers | [142] |
Broilers 1-day-old | 300, 600Â mg/kg | E. coli, 42-d feeding | Increased ADG and decreased FCR of broilers challenged with E. coli; increased villus length to crypt depth and decreased E. coli number in challenged chickens | [143] |
Ducks 1-day-old | 500Â mg/kg | Aflatoxin B1, 42-d feeding | Increase II-phase enzyme activity, activate NRF2 signal pathway, and protect oxidative stress and inflammatory reaction in the liver induced by AFB1 | [144] |
Ducks 1-day-old | 500 mg/kg | Aflatoxin B1, 70-d feeding | Alleviated ileum injury induced by AFB1, decreased the production of AFB1-DNA adducts and reduced DNA damage and oxidative stress via NRF2/KEAP1 and NF-κB/NLRP3 signaling pathways | [145] |
Chicken 1-day-old | 200, 400 and 800Â mg/kg | Conventional vaccinations, 40-d feeding | Increased ADG and antibody titers against Newcastle disease virus and avian influenza viruses H5 and H9 | [146] |
Ducks 1-day-old | 400Â mg/kg | LPS treatment, 28-d feeding | Improved final BW and ADG before LPS treatment; alleviated LPS-induced inflammatory response in liver and intestine and increased tight junction protein expression | |
Ducks 1-day-old | 300, 400 and 500Â mg/kg | 70-d feeding | Increased pH and reduced MDA, carbonyl contents, and shear force, thereby improving water mobility and distribution, drip loss and cooking loss of duck meat; inhibited the formation of carbonyl and dityrosine and reduced the loss of sulfhydryl in frozen-thawed duck breast meat | |
Quails 55-day-old | 200, 400 mg/kg | Heat stress, 12-week feeding | Increased ADFI and egg production; increased hepatic SOD, CAT, and GPX activities as well as NRF2 expression, decreased hepatic MDA concentrations and Hsp70, Hsp90, and NF-κB expressions | [151] |
Black-boned chickens 42-day-old | 200, 400 and 600Â mg/kg | Heat stress, 15-d feeding | Increased feed intake and BW gain; improved villus morphology, numbers of goblet cells and lymphocytes and regulated heat shock protein expression in the thymus and intestine | |
Broilers 21-day-old | 400Â mg/kg | Heat stress, 21-d feeding | Increased final BW of heat-stressed broilers; decreased crypt depth and E. coli populations, and increased villus height, goblet cells numbers, populations of Lactobacillus and Bifidobacterium; Increased a*, pH24h, and decreased L*, drip loss and muscle MDA content of heat-stress broilers | |
Broilers 28-day-old | 200, 350, and 500Â mg/kg | Heat stress, 14-d feeding | Improved ADG and decreased rectal temperature of heat-stressed broilers; lowered contents of corticosterone and adrenocorticotropic hormone | [154] |
Broilers 28-day-old | 500 mg/kg | Heat stress, 14-d feeding | Increased ADFI and ADG under heat stress; decreased crypt depth, increased villus height; increased gene expression related to gut barrier and decreased gene expression related to inflammation; improved immune organ index and inhibited the NF-κB, MAPK, and PI3K/AKT signaling pathway in spleen | |
Broilers 21-day-old | 400Â mg/kg | Heat stress, 21-d feeding | Increased BW and ADG under heat stress; increased relative jejunum weight, relative length of ileum, jejunal villus height, activities of GPX and GST, and mRNA levels of NRF2 and SOD1 under heat stress | [156] |
Ducks 60-day-old | 400Â mg/kg | Heat stress, 15-d feeding | Increased the ratio of villus height to crypt depth and the number of goblet cells and reduced the histopathological damage of jejunum; activated SIRT1-NRF1/NRF2 signaling pathways, improved ATP level of jejunum | [157] |
Broilers 28-day-old | 500Â mg/kg | Heat stress, 14-d feeding | Decreased FCR under heat stress; decreased levels of corticosterone and adrenocorticotropic hormone caused and reduced heat stress-induced apoptotic cells and apoptosis genes | [158] |