Table 2 Significantly enriched pathways for the input list of the collected candidate genes obtained from KEGG and REACTOME
From: Candidate genes for mastitis resistance in dairy cattle: a data integration approach
KEGG: Term name | Term ID | P adj | Genes in pathway |
ABC transporters | KEGG:02010 | 6.115 × 10−12 | ABCA4, ABCA7, ABCB1, ABCC2, ABCD4, ABCG2, ABCG5 |
Viral protein interaction with cytokine and cytokine receptor | KEGG:04061 | 3.263 × 10−8 | ACKR3, CCL11, CCL16, CCL19, CCL2, CCL20, CCL28, CCL3, CCL4, CCL5, CCR1, CCR2, CCR5, CCR7, CXCL1, CXCL10, CXCL11, CXCL2, CXCL5, CXCL8, CXCR1, CXCR2, CXCR4, GRO1, IL10RA, IL10RB, IL18, IL18RAP, IL2, IL20RA, IL20RB, IL2RG, IL34, IL6 |
Bile secretion | KEGG:04976 | 3.718 × 10−4 | ABCB1, ABCC2, ABCG2, ABCG5 |
Cytokine-cytokine receptor interaction | KEGG:04060 | 6.366 × 10−4 | ACKR3, AMH, BMP7, CCL11, CCL16, CCL19, CCL2, CCL20, CCL28, CCL3, CCL4, CCL5, CCR1, CCR2, CCR5, CCR7, CD4, CD40, CSF2, CSF2RB, CSF3, CX3CL1, CXCL10, CXCL11, CXCL16, CXCL2, CXCL5, CXCL8, CXCR1, CXCR2, CXCR4, FAS, GDF10, GDF9, GHR, GRO1, IFNAR2, IFNB, IFNB2, IL10RA, IL10RB, IL11, IL17A, IL17F, IL18, IL18RAP, IL1A, IL1B, IL1RAP, IL1RN, IL2, IL20RA, IL20RB, IL21, IL23A, IL2RG, IL31RA, IL34, IL36A, IL4R, IL6, INHBB |
Hematopoietic cell lineage | KEGG:04640 | 2.008 × 10−3 | BOLA-DOB, BOLA-DQA2, BOLA-DQA5, BOLA-DRB3, CD14, CD1E, CD34, CD36, CD37, CD38, CD3E, CD4, CD44, CD55, CD8A, CD8B |
REACTOME: Term name | Term ID | P adj | Genes in pathway |
Chemokine receptors bind chemokines | REAC:R-BTA-380,108 | 3.344 × 10−5 | ACKR3, CCL11, CCL16, CCL19, CCL2, CCL20, CCL28, CCL3, CCL4, CCL5, CCR1, CCR2, CCR5, CCRL2, CXCL13, CXCL16, CXCR4 |
Senescence-Associated Secretory Phenotype (SASP) | REAC:R-BTA-2,559,582 | 4.729 × 10−2 | CDK6, CDKN2B, CDKN2C, CEBPB |