Table 1 List of the most promising (associated with mastitis in multiple independent studies, regardless of study approach) candidate genes for mastitis resistance

BoLA-DRB3

Major histocompatibility complex, class II, DRB3

23

ENSBTAG00000013919

13

/

SCS

[31, 53,54,55,56,57,58,59,60,61,62,63,64]

C6

Complement C6

20

ENSBTAG00000014177

3

2

/

[65,66,67,68,69]

C9

Complement C9

20

ENSBTAG00000016149

4

1

/

[66,67,68, 70, 71]

CACNA2D1

Calcium voltage-gated channel auxiliary subunit alpha2delta 1

4

ENSBTAG00000020569

4

2

/

[60, 72,73,74,75,76]

CARD6

Caspase recruitment domain family member 6

20

ENSBTAG00000014374

3

/

/

[66, 68, 77]

CD14

CD14 molecule

7

ENSBTAG00000015032

4

3

/

[31, 34, 37, 78,79,80,81]

CXCL8

C-X-C motif chemokine ligand 8 (interleukin 8)

6

ENSBTAG00000019716

18

10

CM

[31, 32, 35, 82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105]

CXCR1

Chemokine (C-X-C motif) receptor 1

2

ENSBTAG00000026753

21

4

/

[31, 82, 83, 106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126]

CXCR2

C-X-C motif chemokine receptor 2

2

ENSBTAG00000038042

3

/

/

[127,128,129]

DCK

Deoxycytidine kinase

6

ENSBTAG00000012397

4

1

/

[70, 118, 130, 131]

DGAT1

Diacylglycerol O-acyltransferase 1

14

ENSBTAG00000026356

5

1

/

[70, 130, 132,133,134,135]

GC

GC vitamin D binding protein

6

ENSBTAG00000013718

7

/

SCS

[71, 131, 132, 134, 136,137,138]

LTF

Lactotransferrin

22

ENSBTAG00000001292

11

7

/

[31, 33, 35, 37, 38, 66, 124, 139,140,141,142,143,144,145,146,147,148,149]

LPAR3

Lysophosphatidic acid receptor 3

3

ENSBTAG00000003791

/

1

Tg

/

[32, 51]

MBL1

Mannose binding lectin, liver (A)

28

ENSBTAG00000054761

6

/

/

[118, 150,151,152,153,154]

MBL2

Mannose binding lectin 2

26

ENSBTAG00000007049

3

/

/

[118, 153, 155]

MFGE8

Milk fat globule EGF and factor V/VIII domain containing

21

ENSBTAG00000003300

/

1

KO

/

[37, 50]

NPFFR2

Neuropeptide FF receptor 2

6

ENSBTAG00000009070

4

/

SCS

[130, 132, 136, 156]

SOCS2

Suppressor of cytokine signaling 2

5

ENSBTAG00000012007

4

4

/

[35, 68, 157,158,159,160,161,162]

STAT5A

Signal transducer and activator of transcription 5 A

19

ENSBTAG00000009496

3

/

CM

[163,164,165]

TLR2

Toll like receptor 2

17

ENSBTAG00000008008

7

10

/

[31, 34, 35, 37, 97, 105, 120, 166,167,168,169,170,171,172,173,174,175]

TLR4

Toll like receptor 4

8

ENSBTAG00000006240

11

17

/

[31, 34, 38, 76, 104, 105, 140, 147, 149, 166, 168, 170, 173, 175,176,177,178,179,180,181,182,183,184,185,186,187,188]