Fig. 2

Results of the candidate gene analysis. A Overlaps between the collected candidate genes found in different studies on ruminants compared to the list of candidate genes reported in multiple studies (considered the most promising candidate genes), showing eight genes in the cross section with reported sequence polymorphisms associated with mastitis resistance and differentially expressed during E. coli and S. aureus intramammary infections. B Pathway enrichment analysis using g:Profiler and Cytoscape showing major biological pathways within the analysed gene set of the most promising candidates (node cutoff: P value = 0.01; Q value = 0.01. C Protein-protein interactions of the 22 most promising candidate genes as suggested by STRING database of which 13 are connected in a network. Different edge colours represent different types of associations (turquoise: known interactions – from curated databases; magenta: known interactions – experimentally determined; green: predicted interactions – gene neighbourhood; red: predicted interactions – gene fusions; blue: predicted interactions – gene co-occurrence; lime: others – text mining; black: others – co-expression; lavender: others – protein homology)