Fig. 5
The relations of P4-PR and E2-ERα signaling to uterine CDO expression. A and B, Relative Cdo mRNA levels in OVX mouse uteri after 0 (control), 2, 6 and 12 h treatments with 100 ng E2 (A) and 2 mg P4 (B). C, CDO IHC staining in OVX mouse uteri after 0 (control) and 12 h 100 ng E2 or 2 mg P4 treatments. Scale bars: 50 μm. D, E and F, Relative Cdo mRNA (D) and protein levels (E and F) in OVX mouse uteri treated with E2 and E2 inhibitor ICI182780 (ICI). G, H and I, Relative Cdo mRNA (G) and protein levels (H and I) in OVX mouse uteri treated with 2 mg P4 and PR inhibitor RU486. Data are presented as Mean ± SEM. Different letters represent significant differences (P < 0.05, n = 3)