Variable | Control | 0.4% Arg |
---|---|---|
Placental concentrations | ||
 NOx, nmol/g tissue | 46.6 ± 2.5 | 57.1 ± 2.9†|
 Putrescine, nmol/g tissue | 49.1 ± 2.0 | 60.5 ± 1.8* |
 Spermidine, nmol/g tissue | 99.4 ± 4.1 | 115 ± 3.0* |
 Spermine, nmol/g tissue | 101 ± 4.6 | 125 ± 4.1* |
 Total polyamines, nmol/g tissue | 250 ± 10 | 301 ± 8.2* |
 BH4, pmol/g tissue | 346 ± 15 | 419 ± 18* |
 cAMP, pmol/g tissue | 202 ± 9.4 | 258 ± 11* |
 cGMP, pmol/g tissue | 15.4 ± 0.8 | 19.2 ± 0.9* |
Placental synthesis | ||
 NO, nmol/g tissue/h | 12.2 ± 0.48 | 15.4 ± 0.68* |
 Putrescine, nmol/g tissue/h | 0.58 ± 0.02 | 0.71 ± 0.03* |
 Spermidine, nmol/g tissue/h | 0.92 ± 0.05 | 1.16 ± 0.06* |
 Spermine, nmol/g tissue/h | 0.91 ± 0.06 | 1.26 ± 0.07* |
 Total polyamines, nmol/g tissue/h | 2.42 ± 0.11 | 3.12 ± 0.13* |
Placental enzyme activity | ||
 cNOS, nmol/g tissue/h | 1.30 ± 0.08 | 1.42 ± 0.09 |
 iNOS, nmol/g tissue/h | 0.43 ± 0.02 | 0.45 ± 0.03 |
 GTP-CH1, nmol/g tissue/h | 1.57 ± 0.10 | 2.09 ± 0.14* |
 ODC, nmol/g tissue/h | 8.66 ± 0.57 | 11.2 ± 0.80†|