Table 3 Genetic parameters of the differentially expressed plasma metabolites in the negative ion modea
Metabolite | Common name | Heritability | Genetic correlations | Phenotypic correlations | ||
|---|---|---|---|---|---|---|
FCR | RFI | FCR | RFI | |||
HMDB0031469 | Asarone | 0.59 ± 0.13 | –0.12 ± 0.22 | –0.01 ± 0.19 | –0.11 ± 0.05 | –0.11 ± 0.06 |
HMDB0000225 | 2-Oxoadipic acid | 0.58 ± 0.13 | 0.44 ± 0.20 | 0.46 ± 0.17 | 0.12 ± 0.05 | 0.19 ± 0.06 |
HMDB0004089 | 2-(Formylamino)benzoic acid | 0.54 ± 0.13 | –0.14 ± 0.23 | –0.25 ± 0.20 | –0.11 ± 0.05 | –0.16 ± 0.06 |
HMDB0000670 | L-Homoarginine | 0.53 ± 0.13 | 0.34 ± 0.23 | 0.37 ± 0.20 | –0.03 ± 0.06 | 0.09 ± 0.06 |
HMDB0035906 | (+)-Alantolactone | 0.51 ± 0.12 | 0.07 ± 0.23 | 0.06 ± 0.20 | –0.04 ± 0.05 | –0.05 ± 0.06 |
HMDB0033338 | Mollicellin F | 0.43 ± 0.13 | 0.38 ± 0.23 | 0.25 ± 0.21 | 0.18 ± 0.05 | 0.19 ± 0.05 |
HMDB0002833 | Testosterone | 0.43 ± 0.12 | –0.58 ± 0.20 | –0.58 ± 0.18 | –0.22 ± 0.05 | –0.23 ± 0.05 |
HMDB0000045 | Adenosine 5'-monophosphate | 0.42 ± 0.12 | 0.51 ± 0.23 | 0.30 ± 0.20 | 0.18 ± 0.05 | 0.18 ± 0.05 |
HMDB0029467 | Eugenitin | 0.42 ± 0.13 | –0.02 ± 0.26 | –0.09 ± 0.22 | 0.03 ± 0.05 | 0 ± 0.06 |
HMDB0000017 | 4-Pyridoxic acid | 0.41 ± 0.13 | 0.28 ± 0.26 | 0.12 ± 0.23 | 0.01 ± 0.05 | –0.04 ± 0.06 |
HMDB0000531 | 3-Hydroxyvaleric acid | 0.41 ± 0.13 | –0.23 ± 0.26 | 0.18 ± 0.23 | 0.07 ± 0.05 | 0.11 ± 0.06 |
HMDB0005814 | Testate | 0.38 ± 0.12 | –0.22 ± 0.26 | –0.09 ± 0.23 | 0.02 ± 0.05 | 0.01 ± 0.06 |
HMDB0002226 | Adrenic acid | 0.37 ± 0.12 | –0.68 ± 0.23 | –0.38 ± 0.21 | –0.15 ± 0.05 | –0.17 ± 0.05 |
HMDB0000575 | DL-Homocystine | 0.36 ± 0.13 | 0.10 ± 0.27 | 0.10 ± 0.24 | 0.16 ± 0.05 | 0.15 ± 0.05 |
HMDB0062219 | (13Z,16Z)-Docosadienoic acid | 0.33 ± 0.12 | –0.67 ± 0.26 | –0.42 ± 0.23 | –0.08 ± 0.05 | –0.11 ± 0.05 |
HMDB0060029 | 5-(3',4',5'-Trihydroxyphenyl)-gamma-valerolactone-O-methyl-O-sulphate | 0.32 ± 0.13 | 0.19 ± 0.28 | 0.13 ± 0.25 | 0.17 ± 0.05 | 0.09 ± 0.05 |
HMDB0003012 | Aniline | 0.28 ± 0.11 | –0.14 ± 0.28 | –0.31 ± 0.24 | –0.02 ± 0.05 | –0.08 ± 0.05 |
HMDB0000634 | Mesaconic acid | 0.28 ± 0.11 | –0.09 ± 0.29 | 0.22 ± 0.26 | –0.03 ± 0.05 | 0.02 ± 0.05 |
HMDB0000054 | Bilirubin | 0.28 ± 0.10 | –0.04 ± 0.28 | 0.03 ± 0.24 | 0 ± 0.05 | –0.01 ± 0.05 |
HMDB0000308 | 3b-Hydroxy-5-cholenoic acid | 0.24 ± 0.12 | 0.39 ± 0.31 | 0.66 ± 0.28 | 0.03 ± 0.05 | 0.06 ± 0.05 |
HMDB0002032 | 8-Oxoguanine | 0.24 ± 0.12 | –0.11 ± 0.32 | 0.01 ± 0.27 | 0 ± 0.05 | 0.03 ± 0.05 |
HMDB0000292 | Xanthine | 0.21 ± 0.11 | 0.03 ± 0.33 | –0.12 ± 0.28 | –0.02 ± 0.05 | –0.06 ± 0.05 |
HMDB0001903 | Calcitriol | 0.21 ± 0.11 | –0.38 ± 0.32 | –0.02 ± 0.29 | –0.05 ± 0.05 | –0.02 ± 0.05 |
HMDB0039275 | Gingerdione | 0.19 ± 0.10 | –0.31 ± 0.32 | –0.31 ± 0.28 | –0.01 ± 0.05 | 0.02 ± 0.05 |
HMDB0000807 | 3-Phosphoglyceric acid | 0.19 ± 0.11 | –0.39 ± 0.35 | –0.21 ± 0.30 | –0.02 ± 0.05 | 0.03 ± 0.05 |
HMDB0000044 | L-Ascorbate | 0.17 ± 0.10 | –0.58 ± 0.31 | –0.37 ± 0.28 | –0.08 ± 0.05 | –0.08 ± 0.05 |
HMDB0000208 | 2-Oxoglutaric acid | 0.17 ± 0.11 | –0.07 ± 0.35 | 0.07 ± 0.31 | 0.02 ± 0.05 | –0.01 ± 0.05 |
HMDB0000812 | N-Acetylaspartic acid | 0.15 ± 0.11 | –0.78 ± 0.37 | –0.55 ± 0.34 | –0.04 ± 0.05 | –0.06 ± 0.05 |
HMDB0001991 | 7-Methylxanthine | 0.14 ± 0.11 | –0.19 ± 0.40 | 0.51 ± 0.33 | –0.11 ± 0.05 | –0.06 ± 0.05 |
HMDB0000786 | Oxypurinol | 0.12 ± 0.11 | –0.06 ± 0.42 | –0.28 ± 0.35 | –0.10 ± 0.05 | –0.14 ± 0.05 |
HMDB0005998 | 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid | 0.12 ± 0.09 | –0.67 ± 0.37 | –0.58 ± 0.33 | –0.10 ± 0.05 | –0.13 ± 0.05 |
HMDB0033704 | Hexose | 0.11 ± 0.10 | 0.12 ± 0.43 | –0.04 ± 0.38 | 0 ± 0.05 | 0.02 ± 0.05 |
HMDB0041610 | Phenylacetaldehyde | 0.10 ± 0.10 | –0.38 ± 0.42 | –0.23 ± 0.38 | –0.16 ± 0.05 | –0.12 ± 0.05 |
HMDB0002580 | Taurolithocholic acid sulfate | 0.10 ± 0.09 | 0.07 ± 0.44 | 0.26 ± 0.38 | 0.04 ± 0.05 | 0.03 ± 0.05 |
HMDB0015302 | Aurorix | 0.09 ± 0.09 | –0.06 ± 0.44 | 0.31 ± 0.39 | –0.02 ± 0.05 | 0.01 ± 0.05 |
HMDB0000202 | Methylmalonic acid | 0.08 ± 0.09 | 0.13 ± 0.50 | –0.45 ± 0.40 | 0 ± 0.05 | –0.05 ± 0.05 |
HMDB0000389 | 2'-Deoxysepiapterin | 0.07 ± 0.09 | 0.63 ± 0.57 | 0.21 ± 0.45 | –0.02 ± 0.05 | –0.01 ± 0.05 |
HMDB0000511 | Decanoic acid | 0.06 ± 0.09 | 0.31 ± 0.54 | 0.73 ± 0.48 | –0.01 ± 0.05 | 0.03 ± 0.05 |
HMDB0035564 | 6,8-Tricosanedione | 0.06 ± 0.08 | - | –0.49 ± 0.59 | - | –0.02 ± 0.05 |
HMDB0011628 | Enoxolone | 0.05 ± 0.10 | 0.67 ± 1.02 | - | - | - |
HMDB0040085 | 2,5-Dipropyl-4-methylthiazole | 0.05 ± 0.10 | 0.38 ± 0.52 | 0.03 ± 0.53 | 0.12 ± 0.05 | 0.02 ± 0.05 |
HMDB0004624 | 3b,7b-Dihydroxy-5-androsten-17-one | 0.05 ± 0.08 | –0.24 ± 0.57 | –0.40 ± 0.49 | –0.03 ± 0.05 | 0 ± 0.05 |