Table 2 Genetic parameters of the differentially expressed plasma metabolites in the positive ion modea
Metabolite | Common name | Heritability | Genetic correlations | Phenotypic correlations | ||
|---|---|---|---|---|---|---|
FCR | RFI | FCR | RFI | |||
HMDB0001008 | Biliverdin | 0.70 ± 0.13 | 0 ± 0.21 | –0.01 ± 0.18 | –0.03 ± 0.06 | –0.03 ± 0.06 |
HMDB0029112 | Tyrosyl-phenylalanine | 0.57 ± 0.13 | 0 ± 0.22 | –0.11 ± 0.19 | –0.02 ± 0.05 | –0.04 ± 0.06 |
HMDB0003154 | Canthaxanthin | 0.38 ± 0.12 | –0.48 ± 0.22 | –0.45 ± 0.20 | –0.09 ± 0.05 | –0.13 ± 0.05 |
HMDB0000501 | 7-Ketocholesterol | 0.36 ± 0.13 | 0.41 ± 0.25 | 0.54 ± 0.22 | 0.07 ± 0.05 | 0.11 ± 0.05 |
HMDB0004983 | Dimethyl sulfone | 0.33 ± 0.12 | 0.40 ± 0.26 | 0.30 ± 0.23 | –0.04 ± 0.05 | 0 ± 0.05 |
HMDB0038824 | Hypoletin 8-gentiobioside | 0.31 ± 0.13 | 0.35 ± 0.29 | 0.32 ± 0.26 | –0.05 ± 0.05 | –0.05 ± 0.05 |
HMDB0000210 | Pantothenic acid | 0.29 ± 0.11 | 0.16 ± 0.26 | 0.20 ± 0.23 | 0.16 ± 0.05 | 0.15 ± 0.05 |
HMDB0011567 | Monoolein | 0.29 ± 0.12 | –0.38 ± 0.26 | –0.27 ± 0.24 | –0.11 ± 0.05 | –0.05 ± 0.05 |
HMDB0000251 | Taurine | 0.28 ± 0.12 | –0.15 ± 0.28 | 0.04 ± 0.25 | 0.04 ± 0.05 | 0.03 ± 0.05 |
HMDB0004992 | Benzocaine | 0.27 ± 0.11 | 0.12 ± 0.28 | 0.03 ± 0.25 | 0.06 ± 0.05 | 0 ± 0.05 |
HMDB0000714 | Hippuric acid | 0.25 ± 0.11 | 0.05 ± 0.28 | –0.10 ± 0.25 | 0.04 ± 0.05 | –0.01 ± 0.05 |
HMDB0003869 | Epsilon-(gamma-glutamyl)-lysine | 0.25 ± 0.11 | 0.19 ± 0.27 | 0.42 ± 0.21 | 0.14 ± 0.05 | 0.20 ± 0.05 |
HMDB0000128 | Guanidineacetic acid | 0.24 ± 0.11 | –0.20 ± 0.29 | 0.06 ± 0.26 | –0.04 ± 0.05 | 0.01 ± 0.05 |
HMDB0000357 | beta Hydroxybutyrate | 0.23 ± 0.10 | 0.25 ± 0.27 | 0.21 ± 0.25 | 0.16 ± 0.05 | 0.14 ± 0.05 |
HMDB0011741 | gamma-Glutamyltyrosine | 0.22 ± 0.10 | –0.42 ± 0.26 | –0.39 ± 0.25 | –0.19 ± 0.05 | –0.18 ± 0.05 |
HMDB0029081 | Tryptophyl-glutamine | 0.19 ± 0.10 | 0.28 ± 0.30 | 0.30 ± 0.27 | 0.04 ± 0.05 | 0.03 ± 0.05 |
HMDB0006709 | Coenzyme Q2 | 0.16 ± 0.10 | 0.11 ± 0.33 | 0.17 ± 0.30 | –0.02 ± 0.05 | –0.03 ± 0.05 |
HMDB0000175 | IMP | 0.16 ± 0.10 | –0.24 ± 0.33 | –0.14 ± 0.30 | 0 ± 0.05 | –0.01 ± 0.05 |
HMDB0028691 | L-Alanyl-L-leucine | 0.15 ± 0.11 | –0.56 ± 0.37 | –0.03 ± 0.31 | 0.06 ± 0.05 | 0.06 ± 0.05 |
HMDB0013651 | 2-(14,15-Epoxyeicosatrienoyl) glycerol | 0.15 ± 0.09 | 0.25 ± 0.33 | 0.26 ± 0.31 | –0.03 ± 0.05 | –0.02 ± 0.05 |
HMDB0000378 | 2-Methylbutyroylcarnitine | 0.14 ± 0.11 | 0.72 ± 0.33 | 0.74 ± 0.35 | 0.20 ± 0.05 | 0.16 ± 0.05 |
HMDB0015655 | Virilon | 0.13 ± 0.11 | 0.43 ± 0.45 | 0.37 ± 0.41 | –0.08 ± 0.05 | –0.09 ± 0.05 |
HMDB0011725 | Sulfosalicylic acid | 0.13 ± 0.09 | 0.38 ± 0.36 | 0.22 ± 0.32 | 0.05 ± 0.05 | 0.04 ± 0.05 |
HMDB0011171 | gamma-Glu-Leu | 0.11 ± 0.09 | 0.08 ± 0.38 | 0.17 ± 0.35 | 0.01 ± 0.05 | 0.01 ± 0.05 |
HMDB0013272 | N-Lauroylglycine | 0.11 ± 0.09 | –0.02 ± 0.39 | 0.08 ± 0.36 | –0.01 ± 0.05 | –0.02 ± 0.05 |
HMDB0000016 | Desoxycortone | 0.11 ± 0.09 | 0.29 ± 0.40 | 0.35 ± 0.36 | –0.02 ± 0.05 | –0.02 ± 0.05 |
HMDB0001072 | Ubiquinone-10 | 0.08 ± 0.09 | –0.47 ± 0.45 | -0.59 ± 0.42 | 0.05 ± 0.05 | 0.04 ± 0.05 |
HMDB0062656 | Linoleamide | 0.08 ± 0.09 | 0.37 ± 0.46 | 0.44 ± 0.42 | –0.04 ± 0.05 | –0.04 ± 0.05 |
HMDB0000201 | Acetyl-L-carnitine | 0.08 ± 0.09 | –0.01 ± 0.42 | 0.13 ± 0.38 | 0.18 ± 0.05 | 0.13 ± 0.05 |
HMDB0031048 | Avocadyne 1-acetate | 0.08 ± 0.09 | 0.28 ± 0.46 | 0.40 ± 0.43 | –0.03 ± 0.05 | –0.03 ± 0.05 |
HMDB0002100 | Palmitoyl ethanolamide | 0.08 ± 0.09 | 0.26 ± 0.47 | 0.40 ± 0.45 | –0.04 ± 0.05 | –0.04 ± 0.05 |
HMDB0001586 | Glucose 1-phosphate | 0.07 ± 0.08 | 0.22 ± 0.46 | –0.10 ± 0.41 | –0.02 ± 0.05 | –0.03 ± 0.05 |
HMDB0002117 | Oleamide | 0.07 ± 0.08 | 0.28 ± 0.48 | 0.34 ± 0.46 | –0.02 ± 0.05 | –0.01 ± 0.05 |
HMDB0041857 | Citrinin | 0.06 ± 0.08 | 0.51 ± 0.56 | 0.67 ± 0.53 | –0.04 ± 0.05 | –0.05 ± 0.05 |