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Table 3 Effect of intrauterine growth retardation (IUGR) on bile acid derivatives in colonic contents of pigs at growing-finishing stages

From: Intrauterine growth retardation affects liver bile acid metabolism in growing pigs: effects associated with the changes of colonic bile acid derivatives

Item, nmol/g

Groups

25 kg

50 kg

100 kg

Apocholic acid

NBW

0.59 ± 0.13ab

0.41 ± 0.10b

1.04 ± 0.29a

IUGR

1.05 ± 0.29

0.36 ± 0.09

1.06 ± 0.50

Cholic acid

NBW

0.38 ± 0.12

0.24 ± 0.02

0.50 ± 0.15

IUGR

0.36 ± 0.11b

0.30 ± 0.05b

0.28 ± 0.03a

Dehydrolithocholic acid

NBW

7.21 ± 1.40b

8.07 ± 1.19b

16.49 ± 4.07a

IUGR

11.06 ± 1.56b

8.87 ± 2.69b

21.08 ± 4.45a

Glycochenodeoxycholic acid

NBW

1.26 ± 0.18b

0.68 ± 0.09b

3.56 ± 1.68a

IUGR

0.76 ± 0.21

0.23 ± 0.08

0.26 ± 0.09

Glycohyodeoxycholic acid

NBW

6.34 ± 0.75a

3.23 ± 0.51b

5.58 ± 2.21ab

IUGR

0.19 ± 0.08

0.45 ± 0.08

1.60 ± 0.57

Hyodeoxycholic acid

NBW

1198.85 ± 200.75

856.68 ± 148.08

896.71 ± 217.13

IUGR

1152.44 ± 199.17

900.32 ± 158.43

61.85 ± 207.73

Hyocholic acid

NBW

23.06 ± 8.01

6.20 ± 1.50

13.2 ± 6.41

IUGR

9.68 ± 2.22

20.92 ± 7.95

8.47 ± 1.69

Isoallolithocholic acid

NBW

8.07 ± 2.26

15.37 ± 2.63

10.98 ± 1.86

IUGR

12.97 ± 4.72

10.72 ± 2.19

19.14 ± 4.54

Isolithocholic acid

NBW

63.54 ± 11.67b

134.43 ± 15.11a

143.25 ± 21.82a

IUGR

83.70 ± 14.70b

101.51 ± 14.68b

228.67 ± 56.47a

Lithocholic acid

NBW

309.90 ± 47.20

338.40 ± 38.31

443.74 ± 78.76

IUGR

334.91 ± 48.28b

290.29 ± 37.27b

503.53 ± 100.52a

α-muricholic acid

NBW

2.29 ± 0.57

1.16 ± 0.30

1.99 ± 0.77

IUGR

1.84 ± 0.46a

1.23 ± 0.27ab

0.83 ± 0.25b

β-muricholic acid

NBW

0.14 ± 0.03

0.06 ± 0.01

0.08 ± 0.02

IUGR

0.15 ± 0.04

0.06 ± 0.01

0.09 ± 0.02

  1. Data are presented as means ± SEM (n = 8−10). a−bDifferent superscript letters in the same row showed significantly different (P < 0.05) at 25, 50, and 100 kg growth stages (P < 0.05); 25, 50, and 100 kg represent the stages when the average BW of NBW pigs reached at 25, 50, and 100 kg BW. NBW, normal birth weight. IUGR, intrauterine growth retardation