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Table 3 Adipose tissue average gene transcription levels (relative quantities; RQ) of ECS-related, lipid metabolism and inflammatory genes of PP dairy cows supplemented with n-3 fatty acids

From: Effects of omega-3 supplementation on components of the endocannabinoid system and metabolic and inflammatory responses in adipose and liver of peripartum dairy cows

 Genes

Treatmenta

 SEM

 P-value

 

Control

FLX

  

 Endocannabinoid-related

  CNR1b

1.65

1.71

0.090

0.672

  CNR2c

0.34

0.30

0.023

0.249

  MGLLd

0.68

0.76

0.082

0.547

  NAPEPLDe

0.02

0.03

0.004

0.120

  FAAHf

0.07

0.08

0.033

0.897

 Lipid metabolism and beta oxidation

  PPARAg

0.08

0.13

0.022

0.217

  PPARGh

0.52

1.35

0.246

0.039

  LIPEi

1.67

12.46

2.894

0.025

  FASNj

0.80

1.97

0.577

0.185

  FABP4k

61.18

147.02

42.787

0.186

  SREBP1l

0.35

0.73

0.093

0.015

  MLXIPLm

0.04

0.15

0.027

0.015

  ACOX1n

0.13

0.53

0.060

 < 0.001

  ACSL1o

0.26

0.62

0.128

0.077

  CPT1Ap

0.02

0.09

0.034

0.144

  CPT2q

0.76

1.00

0.122

0.205

 Inflammation

  TNFAr

0.005

0.003

0.001

0.227

  IL1Bs

0.02

0.01

0.010

0.296

  IL6t

0.60

0.57

0.077

0.835

  NFKB1u

0.06

0.11

0.034

0.327

  TLR4v

0.15

0.12

0.03

0.496

  CD14w

0.55

0.52

0.05

0.706

  PTGS2x

0.68

0.76

0.082

0.547

  PLA2y

0.36

0.29

0.067

0.489

  IL10z

0.007

0.009

0.002

0.480

  1. aDairy cows were divided into two nutritional regiment groups from −21 to 60 days PP; 1) Control group (CTL)—a standard Israeli diet, 2) FLX—a standard diet supplemented with flaxseed oil containing n-3. bCannabinoid-1 receptor; cCannabinoid-2 receptor; dMonoglyceride lipase; eN-Acyl phosphatidylethanolamine phospholipase D; fFatty acid amide hydrolase; gPeroxisome proliferator activated receptor alpha; hPeroxisome proliferator activated receptor gamma; iLipase E, hormone sensitive type; jFatty acid synthase; kFatty acid binding protein 4; lSterol regulatory element binding transcription factor 1; mCarbohydrate response element binding protein; nAcyl-CoA oxidase; oAcyl-CoA synthetase long chain family member 1; pCarnitine palmitoyltransferase 1; qCarnitine palmitoyltransferase 2; rTumor necrosis factor α; sInterleukin 1 beta; tInterleukin 6; uNuclear factor kappa-light-chain-enhancer of activated B cells; vToll like receptor 1; wCD14 molecule 10; xProstaglandin endoperoxide synthase 2; yPhospholipase A2 group IIA; zInterleukin 10