Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs

Table 6 Effect of PFAs on immunoglobulins and cytokines in weaned pigs challenged with E. coli¹

Items	NC	PC	T1	T2	T3	T4	T5	SEM	P-value
d 0
IgG, mg/dL	219.67	215.00	220.33	215.33	216.67	219.33	218.67	9.251	0.999
IgA, mg/dL	1.67	1.67	1.33	1.33	1.67	1.67	1.33	0.167	0.350
TNF-α, pg/mL	43.80	43.08	44.20	40.11	41.53	42.39	41.09	1.874	0.704
IL-6, pg/mL	50.93	53.30	52.43	55.30	51.20	52.37	50.33	5.217	0.996
d 7 PI
IgG, mg/dL	177.67^a	127.00^c	143.33^bc	153.67^abc	157.67^ab	149.00^bc	147.67^bc	8.809	0.012
IgA, mg/dL	1.33^a	1.00^b	1.00^b	1.00^b	1.33^a	1.33^a	1.00^b	0.109	0.024
TNF-α, pg/mL	37.14^b	51.55^a	30.71^bc	28.82^bc	26.86^c	30.12^bc	24.47^c	2.098	0.001
IL-6, pg/mL	49.58^ab	57.50^a	40.93^ab	46.47^ab	32.43^b	50.90^ab	49.33^ab	4.360	0.007
d 14 PI
IgG, mg/dL	178.33	143.67	148.67	171.00	176.67	160.00	153.00	9.775	0.077
IgA, mg/dL	1.33	1.33	1.00	1.33	1.33	1.33	1.00	0.141	0.258
TNF-α, pg/mL	38.46^ab	47.25^a	46.62^a	30.37^ab	23.67^b	22.65^b	23.33^b	4.000	0.001
IL-6, pg/mL	44.20	45.27	34.40	29.87	38.90	37.43	44.27	4.133	0.087

¹Abbreviations: NC Basal diet without E. coli challenge (negative control), PC Basal diet with E. coli challenge (positive control), T1 PC + 0.04% PFA1, T2 PC + 0.01% PFA2, T3 PC + 0.10% PFA3, T4 PC + 0.04% PFA4, T5 PC + 0.10% PFA5, PI Post-inoculation, IgG Immunoglobulin G, IgA Immunoglobulin A, TNF-α Tumor necrosis factor α, IL-6 Interleukin-6, SEM Standard error of mean
^{a -c}Means with different letters are significantly differ (P < 0.05)

ISSN: 2049-1891