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Table 3 Information of 10-SNP windows explaining more than 0.15% of the total additive genetic variance for rectal temperature, respiration rate score, and drooling score in Holstein cattle

From: Weighted single-step GWAS and RNA sequencing reveals key candidate genes associated with physiological indicators of heat stress in Holstein cattle

Trait

Chromosome

Regions, Mb

Genetic variance explained, %

Candidate genes

Rectal temperature

BTA3

27.97–28.20

0.21

NGF,

BTA4

24.75–24.97

0.17

CRPPA, SOSTDC1

BTA5

11.11–11.25

0.23

PPFIA2

BTA6

52.82–53.08

0.2

 

BTA6

60.70–60.82

0.16

TMEM33

BTA8

79.10–79.56

0.25

NAA35, GOLM1, ISCA1, TUT7

BTA14

21.35–21.36

0.24

 

BTA14

73.81–74.05

0.15

OSGIN2, RIPK2

BTA21

46.59–46.82

0.19

NKX2–1, NKX2–8

BTA22

3.39–3.57

0.4

 

BTA24

58.68–58.86

0.22

PMAIP1

BTA25

25.60–25.89

0.19

XPO6, SBK1, LAT, SPNS1, NFATC2IP

BTA28

5.81–5.96

0.15

NTPCR, PCNX2

BTA29

38.30–38.69

0.18

PAG14, PAG16, PAG20, PAG21, PAG1, PAG19

Respiration rate score

BTA1

11.73–11.92

0.2

 

BTA1

63.04–63.26

0.17

 

BTA2

11.79–11.95

0.16

 

BTA3

0.45–0.61

0.19

TIPR, GPR161, DCAF6

BTA7

71.05–71.22

0.15

 

BTA8

68.94–69.08

0.18

GFRA2

BTA8

71.00–71.19

0.16

 

BTA9

43.41–43.64

0.22

RTN4IP1, CRYBG1

BTA9

100.64–100.81

0.18

PDE10A

BTA12

20.93–21.07

0.16

WDFY2

BTA12

21.84–22.08

0.21

MRPS31, FOXO1

BTA14

21.59–21.61

0.37

 

BTA14

61.23–61.38

0.22

BAALC

BTA15

26.67–26.84

0.28

 

BTA17

6.06–6.22

0.15

GATB; FAM160A1

BTA23

1.11–1.50

0.2

 

BTA24

36.50–36.82

0.19

 

BTA29

4.88–5.08

0.18

CHORDC1

BTA30

120.98–121.08

0.17

 

Drooling score

BTA3

31.88–32.01

0.19

OVGP1

BTA3

49.52–49.63

0.26

ABCA4, GCLM, DNTTIP2

BTA3

51.62–51.85

0.16

TGFBR3

BTA3

52.17–52.2

0.18

 

BTA3

53.14–53.3

0.18

ZNF326

BTA3

55.66–56.01

0.16

 

BTA6

37.35–37.38

0.16

NCAPG

BTA6

38.20–38.23

0.21

 

BTA11

34.30–34.71

0.17

 

BTA11

34.86–35.08

0.21

 

BTA12

65.62–65.83

0.18

GPC5

BTA12

65.96–66.18

0.27

GPC5

BTA13

49.30–49.48

0.16

 

BTA13

55.36–55.62

0.25

 

BTA14

25.58–25.73

0.15

 

BTA16

9.08–9.30

0.20

 

BTA16

69.97–70.17

0.25

 

BTA21

24.80–24.94

0.33

HDGFL3, TM6SF1

BTA21

57.87–58.10

0.17

BTBD7, UNC79

BTA24

47.70–47.91

0.17

ZBTB7C