Establishment of a male fertility prediction model with sperm RNA markers in pigs as a translational animal model

Table 3 Male fertility prediction value of multiple marker models

Prediction model	AUC	Sensitivity, %	Specificity, %	NPV, %	PPV, %	OA, %
EQTN-ZP4	1.0	100.0	100.0	100.0	100.0	100.0
ZP4-UNC13B	1.0	100.0	100.0	100.0	100.0	100.0
ZP4-RIMS1	1.0	100.0	100.0	100.0	100.0	100.0
UNC13B-CD9	0.6	50.0	50.0	50.0	50.0	50.0
IZUMO1R-SPACA3	0.8	70.0	60.0	66.7	63.6	65.0
IZUMO1-SYT6	0.7	70.0	60.0	66.7	63.6	65.0
SPACA3-CD9	1.0	90.0	80.0	88.9	81.8	85.0
CD9-RAB3A	0.8	80.0	80.0	80.0	80.0	80.0
CD9-SYT6	0.8	70.0	70.0	70.0	70.0	70.0
UNC13B-IZUMO1-SYT6	0.7	70.0	60.0	66.7	63.6	65.0
UNC13B-SPACA3-CD9	0.9	80.0	80.0	80.0	80.0	80.0
UNC13B-CD9-SYT6	0.7	70.0	70.0	70.0	70.0	70.0
RIMS1-SPACA3-CD9	0.9	80.0	80.0	80.0	80.0	80.0
RIMS1-CD9-SYT6	0.7	70.0	60.0	66.7	63.6	65.0

AUC Area under the curve. Sensitivity is the percentage of pigs showing true-positive results when tested with mRNA expression. Specificity is the percentage of pigs showing true-negative results. The positive predictive value (PPV) is the percentage of pigs that tested as positive and simultaneously has a true-positive litter size. The negative predictive value (NPV) is the percentage of pigs that tested as negative or simultaneously had a true-negative litter size. OA overall accuracy

ISSN: 2049-1891