Fig. 5

Pathway analysis of differentially expressed miRNA target genes. Bubble plots for the pathways targeted by the elevated miRNAs in the high (A) and low quality (B) s-EVs groups and by the top five most abundant miRNAs in both groups (C). The color and size of each bubble represent the P-value and the number of miRNA target genes in each pathway, respectively. Exclusive and common pathways targeted by elevated miRNAs in the high- (HQ) and low-quality (LQ) s-EVs groups and by the top five most abundant miRNAs in both groups (D)