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Fig. 8 | Journal of Animal Science and Biotechnology

Fig. 8

From: Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets

Fig. 8

Knockdown of TGR5 abolished the TUDCA-improved epithelial barrier impairment in E. coli-treated IPEC-J2 cells. A-D Western blotting measurements of the protein levels of ZO-1, OCC and Claudin-1 in IPEC-J2 cells after treatment with TUDCA and/or E. coli and/or TGR5 siRNA. Tubulin was used as the loading control (n = 4). E The intracellular cAMP level in IPEC-J2 cells (n = 6). ∗P < 0.05. NS = not significant

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Journal of Animal Science and Biotechnology

ISSN: 2049-1891